The changing nature of avian influenza A virus (H5N1).

Watanabe Y.; Ibrahim M. S.; Suzuki Y.; Ikuta K.

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The changing nature of avian influenza A virus (H5N1).

机译：甲型禽流感病毒（H5N1）的不断变化的性质。

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Highly pathogenic avian influenza A virus subtype H5N1 has been endemic in some bird species since its emergence in 1996 and its ecology, genetics and antigenic properties have continued to evolve. This has allowed diverse virus strains to emerge in endemic areas with altered receptor specificity, including a new H5 sublineage with enhanced binding affinity to the human-type receptor. The pandemic potential of H5N1 viruses is alarming and may be increasing. We review here the complex dynamics and changing nature of the H5N1 virus that may contribute to the emergence of pandemic strains.Digital Object Identifier http://dx.doi.org/10.1016/j.tim.2011.10.003

机译：自1996年出现以来，高致病性甲型H5N1禽流感病毒已在某些鸟类中流行，其生态，遗传和抗原特性也在不断发展。这已使各种病毒株以改变的受体特异性出现在流行地区，包括与人型受体结合亲和力增强的新H5亚系。 H5N1病毒的大流行潜力令人担忧，并且可能正在增加。我们在这里回顾了可能导致大流行毒株出现的H5N1病毒的复杂动力学和变化的性质。数字对象标识符http://dx.doi.org/10.1016/j.tim.2011.10.003

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《Trends in Microbiology》 |2012年第1期|共10页
作者
Watanabe Y.; Ibrahim M. S.; Suzuki Y.; Ikuta K.;
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正文语种 eng
中图分类微生物学;
关键词
antigenic variation; genetic variation; human diseases; influenza A; molecular epidemiology; molecular genetics; poultry; reviews; strains; fowls; Influenza A virus; man; Gallus gallus; Gallus; Phasianidae; Galliformes; birds; vertebrates; Chordata; animals; eukaryotes; Influenzavirus A; Orthomyxoviridae; negative-sense ssRNA viruses; ssRNA viruses; RNA viruses; viruses; Homo; Hominidae; Primates; mammals; antigenic polymorphism; biochemical genetics; chickens; domesticated birds; genetic variability; genotypic variability; genotypic variation; H5N1 subtype influenza A virus;

机译：抗原变异;遗传变异;人类疾病;甲型流感;分子流行病学;分子遗传学;家禽;综述;毒株;禽类;甲型流感病毒;人;鸡鸡;鸡;鸡;Ph科;鸡形目;鸟;脊椎动物;梭子鱼;动物;真核生物;甲型流感病毒;正粘病毒科;负义ssRNA病毒;ssRNA病毒;RNA病毒;病毒;人;人科;灵长类动物;哺乳动物;抗原多态性;生化遗传学;鸡;家禽;遗传变异;基因型变异;基因型亚型;5甲型流感病毒;

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1. Intranasal administration of a live non-pathogenic avian H5N1 influenza virus from a virus library confers protective immunity against H5N1 highly pathogenic avian influenza virus infection in mice: Comparison of formulations and administration routes of vaccines [J] . Kashima Yoshitaka, Ikeda Mizuho, Itoh Yasushi, Vaccine . 2009,第52期

机译：从病毒库经鼻内施用活的非致病性禽H5N1流感病毒可赋予小鼠抗H5N1高致病性禽流感病毒感染的保护性免疫：疫苗制剂和给药途径的比较
2. Mucosal administration of raccoonpox virus expressing highly pathogenic avian H5N1 influenza neuraminidase is highly protective against H5N1 and seasonal influenza virus challenge [J] . Kingstad-Bakke Brock, Kamlangdee Attapon, Osorio Jorge E. Vaccine . 2015,第39期

机译：表达高致病性禽H5N1流感神经氨酸酶的浣熊病毒的粘膜给药对H5N1和季节性流感病毒挑战具有高度保护作用
3. Inactivated influenza H5N1 whole-virus vaccine with aluminum adjuvant induces homologous and heterologous protective immunities against lethal challenge with highly pathogenic H5N1 avian influenza viruses in a mouse model [J] . Ninomiya A, Imai M, Tashiro M, Vaccine . 2007,第18期

机译：铝佐剂灭活的H5N1流感全病毒疫苗在小鼠模型中诱导针对高致病性H5N1禽流感病毒致死性攻击的同源和异源保护性免疫
4. The Effect of Spirulina as Feed Additive to Myocardial Necrosis and Leukocyte of Chicken with Avian Influenza (H5N1) Virus Infection [C] . Widya Paramita Lokapirnasari, Andreas Berny Yulianto, Djoko Legowo, International Seminar on Molecular and Cellular Life Sciences . 2016

机译：螺旋藻作为饲料添加剂对心肌坏死和白细胞的饲料添加剂，禽流感（H5N1）病毒感染
5. Estimating evolutionary history and geographic spread of Highly Pathogenic Avian Influenza (HPAI) H5N1 virus. [D] . Manthena, Varuna. 2015

机译：估计高度致病性禽流感（HPAI）H5N1病毒的进化历史和地理分布。
6. Recombinant Parainfluenza Virus 5 Expressing Hemagglutinin of Influenza A Virus H5N1 Protected Mice against Lethal Highly Pathogenic Avian Influenza Virus H5N1 Challenge [O] . Zhuo Li, Alaina J. Mooney, Jon D. Gabbard, 2013

机译：表达重组甲型流感病毒H5N1血凝素的副流感病毒5保护小鼠免受致死性高致病性禽流感病毒H5N1挑战
7. Attenuation of highly pathogenic avian influenza A(H5N1) viruses in Indonesia following the reassortment and acquisition of genes from low pathogenicity avian influenza A virus progenitors [O] . Ni Luh Putu Indi Dharmayanti, Sharmi W. Thor, Natosha Zanders, 2018

机译：在排序和获取来自低致病性禽流感的基因之后，印度尼西亚高致病性禽流感A（H5N1）病毒的病毒

The changing nature of avian influenza A virus (H5N1).

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