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Split personalities

机译：个性分裂

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The recent lull in the completion of microbial genomes has been broken by the publication of the complete genome sequences of three very different bacteria. The diversity of these organisms is not only reflected in their ecology, but also in their genomic contents and constituents. Comparative genomics has been taken one step further by two independent groups that have sequenced the genome of Agrobacterium tumefaciens C58 [1,2]. A. tumefaciens is the causative agent of crown gall disease in plantsand is most widely known for its ability to transfer and integrate a segment of its DNA into eukaryotic genomes. The two published genomes are very similar in size, the Goodner et al. sequence being slightly larger owing to two small insertions. In total, the genome is 5.67 Mb in size and comprises an unusual combination of four replicons: a circular chromosome, a linear chromosome plus two plasmids: pTIC58 (a tumor-inducing plasmid) and pATC58. The linear chromosome contains covalently closed telomeres, but also displays several features reminiscent of plasmids, including conjugative proteins and a RepABC-type replication system. Interestingly, although the genomes are almost identical, the total number of predicted coding sequences (CDS) from each group varies, highlighting the problems associated with standardizing CDS prediction.
机译：三种不同细菌完整基因组序列的出版打破了微生物基因组完成的近期停滞。这些生物的多样性不仅反映在其生态上，而且反映在它们的基因组含量和组成上。比较基因组学已由两个独立的小组又向前迈进了一步，这两个小组对根癌土壤杆菌C58的基因组进行了测序[1,2]。根癌农杆菌是植物中冠状disease病的病原体，并且因其将DNA的一部分转移并整合到真核基因组中的能力而广为人知。 Goodner等人，两个已发表的基因组在大小上非常相似。由于两次小的插入，序列稍大。总的来说，基因组的大小为5.67 Mb，包含四个复制子的不寻常组合：环形染色体，线性染色体以及两个质粒：pTIC58（诱导肿瘤的质粒）和pATC58。线性染色体包含共价封闭的端粒，但也显示出一些让人联想到质粒的特征，包括结合蛋白和RepABC型复制系统。有趣的是，尽管基因组几乎相同，但是每组中预测的编码序列（CDS）的总数各不相同，这突出了与标准化CDS预测相关的问题。

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