Virus-like particles as immunogens

Rob Noad; Polly Roy

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Virus-like particles as immunogens

机译：病毒样颗粒作为免疫原

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Subunit vaccines based on recombinant proteins can suffer from poor immunogenicity owing to incorrect folding of the target protein or poor presentation to the immune system. Virus-like particles (VLPs) represent a specific class of subunit vaccine that mimic the structure of authentic virus particles. They are recognized readily by the immune system and present viral antigens in a more authentic conformation than other subunit vaccines. VLPs have therefore shown dramatic effectiveness as candidate vaccines. Here, we review the current status of VLPs as vaccines, and discuss the characteristics and problems associated with producing VLPs for different viruses.

机译：基于重组蛋白的亚单位疫苗由于靶蛋白的错误折叠或向免疫系统的展示不佳而可能导致免疫原性下降。病毒样颗粒（VLP）代表一类特定的亚单位疫苗，可模仿真实病毒颗粒的结构。它们很容易被免疫系统识别，并以比其他亚单位疫苗更真实的构象呈递病毒抗原。因此，VLP已显示出作为候选疫苗的巨大功效。在这里，我们回顾了VLP疫苗的现状，并讨论了针对不同病毒生产VLP的特征和问题。

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《Trends in Microbiology》 |2003年第9期|共7页
作者
Rob Noad; Polly Roy;
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正文语种 eng
中图分类微生物学;
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1. Design, display and immunogenicity of HIV1 gp120 fragment immunogens on virus-like particles [J] . Mansi Purwar, Jonathan K. Pokorski, Pranveer Singh, Vaccine . 2018,第42期

机译：HIV1 GP120片段免疫原的设计，显示和免疫原性在病毒样颗粒上
2. Virus-like particles: potential veterinary vaccine immunogens. [J] . Liu F, Ge S, Li L, Research in Veterinary Science . 2012,第2期

机译：病毒样颗粒：潜在的兽医疫苗免疫原。
3. A plasmid DNA immunogen expressing fifteen protein antigens and complex virus-like particles (VLP+) mimicking naturally occurring HIV [J] . Somogyi Eszter, Xu Jianqing, Gudics Agnes, Vaccine . 2011,第4期

机译：表达15种蛋白抗原和模仿天然HIV的复杂病毒样颗粒（VLP +）的质粒DNA免疫原
4. Hybrid organic-inorganic nanoparticles: controlled incorporation of gold nanoparticles into virus-like particles and application in surface-enhanced Raman spectroscopy [C] . Marcus Niebert, James Riches, Mark Howes, Smart Materials IV; Proceedings of SPIE-The International Society for Optical Engineering; vol.6413 . 2006

机译：杂化有机-无机纳米粒子：将金纳米粒子受控掺入病毒样粒子中，并在表面增强拉曼光谱中的应用
5. Self-assembled virus-like particles and their applications in nanomedicine Optimization of core nanoparticle synthesis [D] . Karacan, Elif 2011

机译：自组装病毒样颗粒及其在纳米药物中的应用核心纳米颗粒合成的优化
6. Human Papillomavirus Virus-Like Particles Are Efficient Oral Immunogens when Coadministered with Escherichia coli Heat-Labile Enterotoxin Mutant R192G or CpG DNA [O] . S. Gerber, C. Lane, D. M. Brown, 2001

机译：当与大肠杆菌热不稳定肠毒素突变体R192G或CpG DNA并用时人乳头瘤病毒病毒样颗粒是有效的口服免疫原
7. Design, display and immunogenicity of HIV1 gp120 fragment immunogens on virus-like particles [O] . Mansi Purwar, Jonathan K. Pokorski, Pranveer Singh, 2018

机译：HIV1 GP120片段免疫原的设计，显示和免疫原性在病毒样颗粒上

Virus-like particles as immunogens

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