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Spin probes for electron paramagnetic resonance imaging

机译：用于电子顺磁共振成像的自旋探针

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摘要

Electron paramagnetic resonance imaging (EPRI) is a relatively recent imaging technique, which provides potentially multidimensional imaging of the spatial distribution of paramagnetic species. Thanks to the use of stable spin probes, low frequency EPR imaging has recently allowed the use of large tissue samples or whole animals in vivo in the field of biology and medicine. It is normally necessary to introduce prior intravenous or intramuscular infusion of stable or slowly metabolizable non-toxic water-soluble paramagnetic materials, or stable implantable particulate materials as spin probes into the system. The classification and research progress of spin probes at present were described briefly. Three important potential approaches in water-soluble paramagnetic materials design including deuterated, site-specific and macromolecular conjugated nitroxides were also investigated.
机译：电子顺磁共振成像（EPRI）是一种相对较新的成像技术，可提供顺磁性物种空间分布的潜在多维成像。由于使用了稳定的自旋探针，低频EPR成像最近已在生物学和医学领域中允许在体内使用大型组织样本或整个动物。通常有必要先将稳定或缓慢代谢的无毒水溶性顺磁性材料或稳定的可植入颗粒材料作为自旋探针进行静脉内或肌肉内输注。简要介绍了目前自旋探针的分类和研究进展。还研究了水溶性顺磁材料设计中的三种重要潜在方法，包括氘化，位点特异性和高分子共轭氮氧化物。

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