In general, PG is also associated with the administration of drugs such as granulocyte colony-stimulating factor,10 antipsychotic agents and IFN-a.Indeed, IFN-oc treatment has some well-known cutaneous side-effects such as dry skin, hair loss and vitiligo. Furthermore, cutaneous ulcerations, indurated erythema and leukocy-toclastic vasculitis may occur at IFN-a injection sites. The pathogenesis of local cutaneous reactions against IFN-a is still unknown. Several case reports have suggested that PG results from IFN-a treatment during the course of hematological malignancies.
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