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首页> 外文期刊>Hepatology: Official Journal of the American Association for the Study of Liver Diseases >Real-time tissue elastography in the assessment of liver stiffness
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Real-time tissue elastography in the assessment of liver stiffness

机译：实时组织弹性成像在评估肝硬度中的作用

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We read with great interest the article by Ochi et al. in the October 2012 issue of Hepatology and would like to express important concerns that arise from the analysis of Fig. 2 in the online version of the article. The figure shows how to obtain the liver elastic ratio, that is, the ratio of strain elastography distribution in two selected regions of interest (ROIs). First, we want to point out that the ROI selected in the two images shown in Fig. 2A and Fig. 2B have different sizes, and both have a size that is much smaller compared with that of strain elas-tography's sample box. We believe that using an adjustable size of an ROI introduces a bias in calculating the elastic ratio. On the other hand, it is well known that in strain elastography the distribution of a color-coded strain in the sample box is complex. The criteria followed in choosing the size of the ROI and in positioning it in the sample box are not stated and they seem fairly subjective. There is a high risk of bias-which could hamper the results-when the examiner subjectively and arbitrarily chooses where to place the ROI for measurements in a complex color-coded strain area. In our opinion, a larger ROI, including all the area of the strain sample box, as has been done in other studies performed using strain elastography, takes into account the complex distribution of the strain. Furthermore, it has been shown that strain elastography shows a patchy pattern of colors as liver fibrosis progresses from hepatitis to cirrhosis, which could be overlooked by selecting a small ROI.
机译：我们非常感兴趣地阅读了Ochi等人的文章。并希望在2012年10月的《肝病》杂志上发表文章，并表达对本文在线版本中对图2的分析引起的重要关注。该图显示了如何获得肝脏弹性率，即在两个选定的感兴趣区域（ROI）中的应变弹性成像分布率。首先，我们要指出的是，在图2A和图2B所示的两个图像中选择的ROI具有不同的大小，并且两者的大小都比应变弹性成像的样本盒小得多。我们认为，使用可调整的ROI大小会在计算弹性比时引入偏差。另一方面，众所周知，在应变弹性成像中，在样品盒中颜色编码的应变的分布是复杂的。没有说明选择ROI大小以及将其放置在样品盒中所遵循的标准，它们似乎相当主观。当检查员主观和任意选择将ROI放置在复杂的颜色编码应变区域中进行测量时，存在很高的偏差风险（可能会妨碍结果）。我们认为，与使用应变弹性成像进行的其他研究一样，更大的ROI（包括应变样品盒的所有区域）都考虑到了应变的复杂分布。此外，已经显示，随着肝纤维化从肝炎发展到肝硬化，应变弹性成像显示出斑驳的颜色图案，可以通过选择小的ROI来忽略它。

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