Protective efficacy of a recombinant BCG secreting antigen 85B/Rv3425 fusion protein against Mycobacterium tuberculosis infection in mice

WangJ.; QieY.; LiuW.; WangH.

首页> 外文期刊>Human vaccines & immunotherapeutics. >Protective efficacy of a recombinant BCG secreting antigen 85B/Rv3425 fusion protein against Mycobacterium tuberculosis infection in mice

【24h】

Protective efficacy of a recombinant BCG secreting antigen 85B/Rv3425 fusion protein against Mycobacterium tuberculosis infection in mice

机译：重组BCG分泌抗原85B / Rv3425融合蛋白对小鼠结核分枝杆菌感染的保护作用

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

In this study, the protective efficacy of a novel recombinant BCG strain co-expressing Ag85B and Rv3425 against Mycobacterium tuberculosis H37Rv was evaluated in mice. This rBCG::Ag85B-Rv3425 strain could provide similar or even better protective efficacy against M. tuberculosis challenge compared with BCG, as shown by no weight loss, significantly reduced lung:body weight ratios and lung bacteria load only at early time of infection. The results suggest that rBCG::Ag85B-Rv3425 could be a potential tuberculosis vaccine candidate for further study.

机译：在这项研究中，评估了小鼠中共表达Ag85B和Rv3425的新型重组BCG菌株对结核分枝杆菌H37Rv的保护作用。该rBCG :: Ag85B-Rv3425菌株与BCG相比，可提供与结核分枝杆菌挑战相似或什至更好的保护功效，如无体重减轻，仅在感染初期显着降低肺：体重比和肺细菌负荷。结果表明，rBCG :: Ag85B-Rv3425可能是潜在的结核病疫苗候选者，需要进一步研究。

著录项

来源
《Human vaccines & immunotherapeutics.》 |2012年第12期|共6页
作者
WangJ.; QieY.; LiuW.; WangH.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Mycobacterium tuberculosis; Recombinant BCG; Rv3425 protein;

机译：结核分枝杆菌;重组卡介苗;Rv3425蛋白;

相似文献

外文文献
中文文献
专利

1. Protective efficacy of a recombinant BCG secreting antigen 85B/Rv3425 fusion protein against Mycobacterium tuberculosis infection in mice [J] . Jiuling Wang, Yaqing Qie, Wei Liu, Human vaccines . 2012,第12期

机译：重组BCG分泌抗原85B / Rv3425融合蛋白对小鼠结核分枝杆菌感染的保护作用
2. Evaluation of immunogenicity and protective efficacy against Mycobacterium tuberculosis infection elicited by recombinant Mycobacterium bovis BCG expressing human Interleukin-12p70 and Early Secretory Antigen Target-6 fusion protein. [J] . Deng Y, Bao L, Yang X Microbiology and Immunology . 2011,第11期

机译：评价表达人白介素12p70和早期分泌抗原Target-6融合蛋白的重组牛分枝杆菌BCG引发的针对结核分枝杆菌感染的免疫原性和保护效果。
3. Efficacy of recombinant bacille Calmette-Guerin vaccine secreting interleukin-15/antigen 85B fusion protein in providing protection against Mycobacterium tuberculosis. [J] . Tang C, Yamada H, Shibata K, The Journal of Infectious Diseases . 2008,第9期

机译：分泌白介素15 /抗原85B融合蛋白的重组杆菌卡介苗疫苗在抵抗结核分枝杆菌中的功效。
4. Study on immunogenicity and protective efficacy of a new vaccine expressing Ag85B and MPT83 fusion protein from Mycobacterium tuberculosis [C] . Yufei Jin, Hong Bao, Jing Chang, International Conference on Human Health and Medical Engineering. . 2014

机译：从结核分枝杆菌中表达AG85B和MPT83融合蛋白的新疫苗免疫原性和保护效果的研究
5. Immunology of BCG vaccination in mice: Implications for tuberculosis vaccination and for the use of BCG as a recombinant vaccine vector. [D] . Power, Carl Andrew. 2000

机译：小鼠BCG疫苗接种的免疫学：对结核疫苗的接种以及BCG作为重组疫苗载体的用途。
6. Protective efficacy of a recombinant BCG secreting antigen 85B/Rv3425 fusion protein against Mycobacterium tuberculosis infection in mice [O] . Jiuling Wang, Yaqing Qie, Wei Liu, 2012

机译：重组卡介苗分泌抗原85B / Rv3425融合蛋白对小鼠结核分枝杆菌感染的保护作用
7. Protective efficacy of a recombinant BCG secreting antigen 85B/Rv3425 fusion protein againstMycobacterium tuberculosisinfection in mice [O] . Jiuling Wang, Yaqing Qie, Wei Liu, 2012

机译：重组BCG分泌抗原85B / RV3425融合蛋白对小鼠结核病的保护效果
8. Effect of Local Ultraviolet Irradiation on Infections of Mice with 'Candida albicans', 'Mycobacterium bovis BCG', and 'Schistosoma mansoni' [R] . Jeevan, A., Evans, R., Brown, E. L., 1992

机译：局部紫外线照射对'白色念珠菌'，'牛分枝杆菌BCG'和'曼氏血吸虫'小鼠感染的影响

Protective efficacy of a recombinant BCG secreting antigen 85B/Rv3425 fusion protein against Mycobacterium tuberculosis infection in mice

摘要

著录项

相似文献

相关主题

期刊订阅