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首页> 外文期刊>Vaccine >An MF59-adjuvanted inactivated influenza vaccine containing A/Panama/1999 (H3N2) induced broader serological protection against heterovariant influenza virus strain A/Fujian/2002 than a subunit and a split influenza vaccine
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An MF59-adjuvanted inactivated influenza vaccine containing A/Panama/1999 (H3N2) induced broader serological protection against heterovariant influenza virus strain A/Fujian/2002 than a subunit and a split influenza vaccine

机译：含有A / Panama / 1999（H3N2）的MF59佐剂灭活流感疫苗诱导的针对异种流感病毒毒株A / Fujian / 2002的血清学保护比亚单位和分裂流感疫苗更广泛

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摘要

To test whether inactivated influenza vaccines distributed during the 2003-2004 influenza season in the northern hemisphere were able to confer protection against the mismatched variant A/Fujian/411/2002 virus strain, we measured haemagglutination inhibiting (HI) antibodies in elderly subjects vaccinated with three inactivated vaccines against the homologous A/H3N2 vaccine strain (A/Panama) and against the mismatched A/Fujian strain. The results showed that, while 76 to 80% of elder people vaccinated with conventional vaccines had protected levels of antibodies against the A/Fujian heterovariant strain, those vaccinated with the MF59-adjuvanted vaccine have protective levels of antibodies in >98% of the cases. We conclude that MF59-adjuvanted vaccines confer protection also against influenza virus strains which are not fully matched with those included in the vaccine.
机译：为了测试在北半球2003年至2004年流感季节期间分发的灭活流感疫苗是否能够针对错配的A / Fujian / 411/2002病毒株提供保护，我们在接种过HBV疫苗的老年受试者中测量了血凝抑制（HI）抗体针对同种A / H3N2疫苗株（A /巴拿马）和错配的A /福建株的三种灭活疫苗。结果表明，虽然接种常规疫苗的老年人中有76％至80％的人具有针对A /福建杂种变异株的抗体保护水平，但接种MF59辅助疫苗的人中有98％以上的病例具有保护性抗体水平。我们得出结论，MF59佐剂疫苗还可以针对未与疫苗中包含的那些完全匹配的流感病毒株提供保护。

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