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Influenza A virus and the cell nucleus

机译:甲型流感病毒和细胞核

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摘要

It is over 20 years since the publication of experiments that showed that influenza A virus RNA synthesis takes place in the cell nucleus and that here, the virus subverts the cellular transcription machinery to express and replicate its own single-strand RNA genome. In the years since, our understanding of the organisation of the nucleus has increased enormously, particularly with regards to the functional integration of the RNA polymerase II transcriptosome. This review summarises recent progress in defining the intimate association between the viral and cellular transcriptional machinery.
机译:自实验发表以来已有20多年的历史了,该研究表明A型流感病毒RNA的合成发生在细胞核中,在这里,该病毒颠覆了细胞转录机制,以表达和复制其自身的单链RNA基因组。从那以后的几年中,我们对细胞核组织的了解大大增加,特别是在RNA聚合酶II转录体的功能整合方面。这篇综述总结了定义病毒和细胞转录机制之间紧密联系的最新进展。

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