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首页> 外文期刊>Vaccine >Towards an oral influenza vaccine: Comparison between intragastric and intracolonic delivery of influenza subunit vaccine in a murine model
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Towards an oral influenza vaccine: Comparison between intragastric and intracolonic delivery of influenza subunit vaccine in a murine model

机译：面向口服流感疫苗：在小鼠模型中胃内和结肠内递送流感亚单位疫苗的比较

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In this paper we investigated to which part of the gastro-intestinal (Gl) tract, the upper or lower part, an oral influenza vaccine should be targeted to result in an effective immune response in mice. Our study demonstrates that without adjuvant substantial systemic but low respiratory mucosal immune responses were induced in mice after delivery of influenza subunit vaccine to the upper Gl-tract (intragastric) as well as the lower Gl-tract (intracoloni-cally). When the vaccine was adjuvanted with Escherichia coli heat-labile enterotoxin (LT) these responses were significantly enhanced. Interestingly, intracolonic administration of vaccine with adjuvant also resulted in enhanced cellular immune responses and the desired Th1 -skewing of these responses. Intragastric administration of the adjuvanted vaccine also increased T-helper responses. However, Th1 -skewing was absent. In conclusion, the right combination of strong mucosal adjuvant (e.g. LT) and antigen delivery site (e.g. the lower part of thegastro-intestinal tract) might result in effective vaccination via the oral route.
机译：在本文中，我们研究了口服流感疫苗应针对胃肠道（Gl）的哪个部分，上部或下部，以在小鼠中产生有效的免疫反应。我们的研究表明，在没有佐剂的情况下，在将流感亚单位疫苗递送至上胃肠道（胃内）和下胃肠道（结肠内）后，在小鼠中诱导了全身性但呼吸道黏膜免疫应答较低。当疫苗与大肠杆菌热不稳定肠毒素（LT）结合使用时，这些反应会明显增强。有趣的是，结肠内给予佐剂疫苗也导致增强的细胞免疫应答和这些应答的所需的Th1-偏斜。胃内给予佐剂疫苗也增加了T辅助反应。但是，没有Th1偏斜。总之，强粘膜佐剂（例如LT）和抗原递送位点（例如胃肠道下部）的正确组合可能会导致通过口服途径进行有效疫苗接种。

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