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New opportunities for cancer prevention

机译:预防癌症的新机会

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Globally, the HPV DNA prevalence in women with normal cytology is found on an average of 10%. As cervical lesions develop the global HPV DNA prevalence increases to 75-85% in LSIL and to 85-100% in HS1L and invasive carcinomas. In cervical cancer cases, the number of types is restricted to 12-15 types, the vast majority of cases harbour only one type and a clear type distribution pattern is found. On worldwide estimates, HPV 16 is consistently the most common type, accounting for some 50% of all cases followed by HPV 18 and 45. Some variability in the ranking thereafter has been described. For the subgroup of cervical adenocarcinomas, HPV 16 and 18 are found in similar proportions followed by HPV 45. The three HPV types combined account for close to75% of the squamous cell carcinomas and close to 90% of the adenocarcinomas.
机译:在全球范围内,细胞学检查正常的女性中HPV DNA的患病率平均为10%。随着宫颈病变的发展,LSIL中的总体HPV DNA患病率增加到75%至85%,HS1L和浸润性癌中则增加至85-100%。在子宫颈癌病例中,类型的数量限制为12-15种,绝大多数病例仅包含一种类型,并且发现了清晰的类型分布模式。在全世界范围内,HPV 16一直是最常见的类型,约占所有病例的50%,其次是HPV 18和45。此后,排名也有所变化。对于子宫颈腺癌亚组,发现HPV 16和18的比例相似,其次是HPV45。这三种HPV类型合起来占鳞状细胞癌的近75%和腺癌的近90%。

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