The rabies peripheral challenge test: more accurate determination of vaccine potency

Wunderli PS; Dreesen DW; Miller TJ; Baer GM

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The rabies peripheral challenge test: more accurate determination of vaccine potency

机译：狂犬病外围攻击测试：更准确地确定疫苗效力

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The National Institutes of Health (NIH) rabies vaccine potency test is used internationally for evaluating the efficacy of inactivated rabies vaccines, despite concerns about its methods. An alternative test has been developed, using a simplified in vivo method for rabies vaccine testing which has several advantages over the currently recommended method of efficacy testing. The rabies peripheral challenge test more closely models practical vaccine application in target species; decreases the observed effect of vaccine virus strain in testing results and allows sensitive analysis of vaccine and production lot testing.

机译：美国国立卫生研究院（NIH）狂犬病疫苗效价测试在国际上用于评估灭活狂犬病疫苗的功效，尽管对其方法有所担忧。已经开发出一种替代测试，该方法使用简化的体内方法进行狂犬病疫苗测试，与目前推荐的功效测试方法相比，具有一些优势。狂犬病外围攻击测试更紧密地模拟了实际疫苗在目标物种中的应用;降低了疫苗病毒株在测试结果中观察到的效果，并允许对疫苗和生产批次测试进行敏感分析。

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《Vaccine》 |2006年第50期|共9页
作者
Wunderli PS; Dreesen DW; Miller TJ; Baer GM;
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正文语种 eng
中图分类卫生标准、卫生检查、医药管理;
关键词
Animals; Enzyme-Linked Immunosorbent Assay; Female; Glycoproteins immunology; Immunization; Injections; Intramuscular; Injections; Intraperitoneal; Mice; Mice; Inbred ICR; Rabies immunology veterinary; Rabies Vaccines administration amp; amp; dosage immunology; Rabies virus immunology; Vaccines; Synthetic immunology; Vaccinia virus immunology;

机译：动物;酶联免疫吸附法;女性;糖蛋白免疫学;免疫接种;注射;肌肉注射;注射;腹膜内;小鼠;小鼠;近交ICR;狂犬病免疫学兽医;狂犬病疫苗施用和剂量免疫学;狂犬病病毒免疫学;狂犬病病毒免疫学牛痘病毒免疫学;

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专利

1. The rabies peripheral challenge test: more accurate determination of vaccine potency [J] . Wunderli PS, Dreesen DW, Miller TJ, Vaccine . 2006,第49a50期

机译：狂犬病外围攻击测试：更准确地确定疫苗效力
2. Potency Testing of Veterinary Rabies Vaccines: Replacement of Challenge by in Vitro Testing Considerations for Development of Alternative Assays [J] . C.E. Lewis, A.M. Fry, J.R. Hermann, Developments in Biologicals . 2012,第期

机译：兽用狂犬病疫苗的效价测试：通过替代测试方法开发中的体外测试考量代替挑战
3. Possibility of Immediate Introduction of a Single-Dose Antibody Induction Test as a Refinement of the NIH Test for Inactivated Rabies Vaccine Potency Determination [J] . Viral immunology . 2020,第5期

机译：直接引入单剂量抗体诱导试验的可能性作为NIH测试的灭活狂犬病疫苗效力测定的细化
4. Size Exclusion Isotope Dilution Mass Spectrometry: An Alternative Assay for Influenza Vaccine Potency Determination [C] . Jonathan L. Bundy, Zsuzsanna Kuklenyik, Yulanda Williamson, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：尺寸排除同位素稀释质谱：流感疫苗效力测定的替代测定
5. Safety and potency testing of veterinary vaccines. [D] . Henderson, Louise Mary. 1993

机译：兽医疫苗的安全性和效力测试。
6. Mouse challenge with Salmonella typhosa in testing the potency of typhoid vaccines [O] . Nusret H. Fisek, S. Gören, N. Akyay 1959

机译：鼠伤寒沙门氏菌对小鼠测试伤寒疫苗效力的挑战
7. Rabies vaccine potency control: Comparison of ELISA systems for antigenicity testing [O] . Rooijakkers E.J.M., Uittenbogaard J.P., Groen J.M. (Jan), 1996

机译：狂犬病疫苗效力控制：用于抗原性测试的ELISA系统的比较

The rabies peripheral challenge test: more accurate determination of vaccine potency

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