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Special Issue: The Development of Dengue Vaccines Introduction

机译:特刊:登革热疫苗的开发简介

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摘要

The disease dengue has been known for several hundred years but it was Benjamin Rush's description of a 1780 Philadelphia epidemic that was the earliest description in English of so-called “break-bone fever”. Subsequently, in 1903, it was demonstrated that the disease was transmitted by Aedes aegypti mosquitoes, and in 1906 it was shown that the causative agent was a virus. In 1944 Albert Sabin identified that two serologically different viruses caused dengue leading to the idea that the disease was caused by multiple serotypes, and in 1956 William Hammon identified two additional serotypes. The idea of four serotypes causing dengue has been maintained over the years but it is clear that the four serotypes are actually four serologically and genetically related, but distinct viruses (DENV-1 to DENV-4).
机译:登革热病已经有数百年的历史了,但本杰明·拉什(Benjamin Rush)对1780年费城疫情的描述是英语中所谓的“断骨热”的最早描述。随后,在1903年,证明该疾病是由埃及伊蚊传播的,在1906年,证明病原体是病毒。 1944年,阿尔伯特·萨宾(Albert Sabin)确定了两种血清学不同的病毒引起了登革热,从而导致该疾病是由多种血清型引起的。1956年,威廉·哈蒙(William Hammon)又发现了两种血清型。导致登革热的四种血清型的想法已保留了多年,但很明显,这四种血清型实际上是四种血清学和遗传相关的病毒,但病毒是不同的(DENV-1至DENV-4)。

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