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首页> 外文期刊>Vaccine >Epidemiology and Natural History of Human Papillomavirus Infections and Type-Specific Implications in Cervical Neoplasia
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Epidemiology and Natural History of Human Papillomavirus Infections and Type-Specific Implications in Cervical Neoplasia

机译：人乳头瘤病毒感染的流行病学和自然史以及宫颈肿瘤的类型特定意义

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Worldwide human papillomavirus (HPV) prevalence in women with normal cytology at any given point in time is approximately 10% indicating that HPV is one of the most common sexually transmitted infections. HPV-16 is consistently the most common type and HPV-18 the second with some minor regional differences. Furthermore, across the spectrum of cervical lesions, HPV-16 is consistently the most common HPV type contributing to 50-55% of invasive cervical cancer cases strongly suggesting that this viral type has a biological advantage for transmission, persistency and transformation. The same phenomenon is observed albeit at a lower level for HPV-18 and HPV-45.Sexual behavioral patterns across age groups and populations are central to the description of the HPV circulation and of the risk of infection. The concept of group sexual behavior (in addition to individual sexual behavior) is important in exploring HPV transmission and has implications for defining and monitoring HPV and cancer prevention strategies.In natural history studies, the pattern of HPV DNA prevalence by age groups is similar to the patterns of HPV incidence. Rates of exposure in young women are high and often include multiple types. There is a spontaneous and rapid decrease of the HPV DNA detection rates in the middle-age groups followed by a second rise in the post-menopausal years. This article reviews: 1) the evidence in relation to the burden of HPV infections in the world and the contributions of each HPV type to the spectrum of cervical cellular changes spanning from normal cytology to invasive cervical cancer; 2) the critical role of the patterns of sexual behavior in the populations; and 3) selected aspects of the technical and methodological complexity of natural history studies of HPV and cervical neoplasia. (C) 2008 Elsevier Ltd. All rights reserved.
机译：在任何给定的时间点，细胞学正常的女性在全世界的人类乳头瘤病毒（HPV）患病率约为10％，表明HPV是最常见的性传播感染之一。 HPV-16始终是最常见的类型，HPV-18则是第二个类型，但区域差异较小。此外，在整个宫颈病变范围内，HPV-16始终是最常见的HPV类型，占侵袭性宫颈癌病例的50-55％，强烈表明该病毒类型具有传播，持久性和转化的生物学优势。尽管HPV-18和HPV-45的水平较低，但仍观察到相同的现象。跨年龄段和人群的性行为方式是描述HPV循环和感染风险的关键。群体性行为（除了个人性行为之外）的概念对于探索HPV传播很重要，并且对定义和监测HPV和癌症预防策略具有重要意义。在自然史研究中，按年龄段划分的HPV DNA流行模式与HPV发病率的模式。年轻女性的接触率很高，通常包括多种类型。在中年年龄组中，HPV DNA的检出率自然而迅速地下降，而在绝经后的岁月中又有第二次上升。本文评论：1）有关世界范围内HPV感染负担的证据以及每种HPV类型对从正常细胞学到浸润性宫颈癌的子宫颈细胞变化谱的贡献; 2）性行为模式在人群中的关键作用;和3）HPV和宫颈癌自然史研究的技术和方法复杂性的某些方面。 （C）2008 Elsevier Ltd.保留所有权利。

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