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首页> 外文期刊>Vaccine >Profiles of B and T cell immune responses elicited by different forms of the hepatitis B virus surface antigen.
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Profiles of B and T cell immune responses elicited by different forms of the hepatitis B virus surface antigen.

机译：不同形式的乙型肝炎病毒表面抗原引起的B和T细胞免疫反应的概况。

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Gene-based hepatitis B virus (HBV) vaccines have been proposed as a novel approach to improve the immunogenicity toward non-responders and to allow for protection against potential viral escape mutants. Furthermore, there is significant interest in using DNA or viral vector vaccines to serve as therapeutic agents to treat chronic HBV infections that are resistant to existing drug therapies. However, the key protective antigen of HBV, the surface protein (HBsAg), can be expressed in three different sizes due to its multiple translational initiation sites: small, middle, and large forms of HBsAg. It is not clear whether the immunogenicity of these HBsAg is same, especially their ability to elicit HBsAg-specific B cell and T cell immune responses in addition to the traditional serum HBsAg-specific antibody responses. In the current study, the immunogenicity of three forms of HBsAg DNA vaccines was analyzed individually in a mouse model. Our results indicated that different forms of the HBsAg have unique immunogenicity profiles and this information is useful for the selection of optimal gene-based HBV vaccines for further improved prophylactic and therapeutic applications.Digital Object Identifier http://dx.doi.org/10.1016/j.vaccine.2010.08.081
机译：已经提出了基于基因的乙型肝炎病毒（HBV）疫苗，作为一种提高对无应答者的免疫原性并允许针对潜在病毒逃逸突变体的保护的新颖方法。此外，使用DNA或病毒载体疫苗作为治疗对现有药物疗法有抗性的慢性HBV感染的治疗剂引起了极大的兴趣。但是，由于其多个翻译起始位点，HBV的关键保护性抗原表面蛋白（HBsAg）可以三种不同大小表达：小，中和大形式的HBsAg。尚不清楚这些HBsAg的免疫原性是否相同，特别是除了传统的血清HBsAg特异性抗体反应外，它们还具有引起HBsAg特异性B细胞和T细胞免疫反应的能力。在当前的研究中，在小鼠模型中分别分析了三种形式的HBsAg DNA疫苗的免疫原性。我们的结果表明，不同形式的HBsAg具有独特的免疫原性特征，该信息可用于选择基于基因的最佳HBV疫苗，以进一步改善预防和治疗应用。数字对象标识符http://dx.doi.org/10.1016 /j.vaccine.2010.08.081

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