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ISCOMATRIX((TM)) adjuvant: a potent inducer of humoral and cellular immune responses

机译：ISCOMATRIX（TM）佐剂：体液和细胞免疫应答的有效诱导剂

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ISCOMATRIX(TM) adjuvant is capable of inducing broad and potent humoral and cellular immune responses. The components are well defined and the manufacturing process is simple and robust. Many vaccines containing the ISCOMATRIX(TM) adjuvant have been tested in a range of animal models, including human and non-human primates. Strong antibody and T cell responses have been induced in these studies [1]. The antibody response is often achieved with lesser amounts of antigen than other adjuvant systems and the maximal responses have also been reached more quickly. Both CD4(+) and CD8(+) T cell responses are induced with the cytotoxic T lymphocyte responses being very long lived. Additionally, ISCOMATRIX(TM) adjuvant can be used in vaccines for induction of mucosal immune responses. This review provides an overview of the immune responses that can be elicited using ISCOMATRIX(TM) vaccines and the current state of knowledge regarding the mechanism of action of this adjuvant.
机译：ISCOMATRIX TM佐剂能够诱导广泛而有效的体液和细胞免疫应答。组件定义明确，制造过程简单而坚固。含有ISCOMATRIX™佐剂的许多疫苗已在多种动物模型（包括人类和非人类灵长类动物）中进行了测试。在这些研究中已经诱导了强烈的抗体和T细胞反应[1]。与其他佐剂系统相比，通常用较少量的抗原即可达到抗体反应，并且也能更快地达到最大反应。 CD4（+）和CD8（+）T细胞反应都被诱导，并且细胞毒性T淋巴细胞反应寿命很长。另外，ISCOMATRIX TM佐剂可用于疫苗中以诱导粘膜免疫应答。该综述概述了使用ISCOMATRIX TM疫苗可引起的免疫应答以及有关该佐剂作用机理的当前知识状态。

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