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首页> 外文期刊>Vaccine >A corn-based delivery system for animal vaccines: an oral transmissible gastroenteritis virus vaccine boosts lactogenic immunity in swine
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A corn-based delivery system for animal vaccines: an oral transmissible gastroenteritis virus vaccine boosts lactogenic immunity in swine

机译：基于玉米的动物疫苗输送系统：口服可传播的胃肠炎病毒疫苗可增强猪的产乳免疫力

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摘要

Recombinant plant expression systems offer a means to produce large quantities of selected antigens for subunit vaccines. Cereals are particularly well-suited expression vehicles since the expressed proteins can be stored at relatively high concentrations for extended periods of time without degradation and dry seed can be formulated into oral vaccines suitable for commercial applications. A subunit vaccine candidate directed against porcine transmissible gastroenteritis virus and expressed in corn seed has been developed for oral delivery to swine. Here, we show that this vaccine, when administered to previously sensitized gilts, can boost neutralizing antibody levels in the animals' serum, colostrum and milk. Thus, this vaccine candidate is effective at boosting lactogenic immunity and is appropriate to pursue through large-scale field trials preceding commercialization.
机译：重组植物表达系统提供了一种为亚单位疫苗生产大量选定抗原的方法。谷物是特别适合的表达载体，因为表达的蛋白质可以在较高的浓度下长时间保存而不会降解，并且干种子可以配制成适合商业用途的口服疫苗。已经开发了针对猪可传播的胃肠炎病毒并在玉米种子中表达的亚单位疫苗候选物，用于口服递送至猪。在这里，我们表明，将这种疫苗与先前致敏的后备母猪一起使用时，可以提高动物血清，初乳和牛奶中的中和抗体水平。因此，该候选疫苗可有效增强乳原性免疫力，适合在商业化之前进行大规模的田间试验。

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