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Influence of the nature of the antigen on the boosting of responses to mycobacteria in M. bovis-BCG vaccinated cattle

机译:抗原的性质对牛分枝杆菌-BCG疫苗接种牛对分枝杆菌反应增强的影响

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摘要

Mycobacterium bovis is the causative agent of bovine tuberculosis (TB) and of a proportion of human TB. Protection against TB requires Th1 responses and worsening of disease is associated with Th2 responses. To help clarify the nature of the response to mycobacteria, the responses from M. bovis-BCG vaccinated cattle boosted with live mycobacteria (BCG), bacterial soluble antigens (PPD) or PBS were evaluated. The results indicated that macrophages may be the major cell population ingesting and presenting mycobacteria in BCG boosted animals, while B-cells seem able to ingest and present PPD to T-cells in PPD boosted animals.
机译:牛分枝杆菌是牛结核病(TB)和一部分人类结核病的病原体。预防结核病需要Th1反应,而疾病恶化与Th2反应相关。为了帮助弄清对分枝杆菌反应的性质,评估了用活分枝杆菌(BCG),细菌可溶性抗原(PPD)或PBS加强接种牛分枝杆菌-BCG的牛的反应。结果表明,巨噬细胞可能是在BCG强化动物中摄取和呈现分枝杆菌的主要细胞群,而B细胞似乎能够在PPD强化动物摄取和呈现PPD到T细胞。

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