...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Vaccine >Adjuvant activity of Quillaja brasiliensis saponins on the immune responses to bovine herpesvirus type 1 in mice
【24h】

Adjuvant activity of Quillaja brasiliensis saponins on the immune responses to bovine herpesvirus type 1 in mice

机译：巴西Quillaja皂苷对小鼠抗1型牛疱疹病毒免疫反应的佐剂活性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The chemical characterization of aqueous extracts (AE) of barks, leaves and branches and the saponin fraction denominated QB-90 obtained from Quillaja brasiliensis, a native species from Southern Brazil, show remarkable similarities to Quillaja saponaria saponins which are known as adjuvants in vaccine formulations.In vivo toxicity assays of AE and QB-90 showed not to be lethal for mice in doses ranging from 50 to 1600 microg and 50-400 microg, respectively. Experimental vaccines prepared with bovine herpesvirus type 1 (BHV-1) antigen and either AE (barks 100 microg, leaves 400 microg, branches 400 microg) or QB-90 (100 microg) were able to enhance the immune responses of mice in a comparable manner to saponins from Q. saponaria (QuilA, 100 microg). BHV-1 specific IgG, IgG1 and IgG2a antibody levels in serum were also significantly enhanced by AE, QB-90 and QuilA compared to control group (p<0.05). These results showed that AE and QB-90 from Q. brasiliensis are potential candidates as adjuvants in vaccines.
机译：树皮，树叶和树枝的水提物（AE）的化学特性以及从巴西南部的巴西种Quillaja brasiliensis获得的命名为QB-90的皂苷组分，与Quillaja saponaria皂苷（在疫苗制剂中被称为佐剂）显示出显着相似性AE和QB-90的体内毒性试验分别对50至1600微克和50-400微克的剂量的小鼠无致命作用。用牛疱疹病毒1型（BHV-1）抗原和AE（树皮100微克，叶400微克，树枝400微克）或QB-90（100微克）制备的实验疫苗能够在类似的条件下增强小鼠的免疫反应皂角苷（QuilA，100微克）中皂苷的制备方法。与对照组相比，AE，QB-90和QuilA也显着提高了血清中BHV-1特异性IgG，IgG1和IgG2a抗体的水平（p <0.05）。这些结果表明来自巴西Q.的AE和QB-90是疫苗佐剂的潜在候选物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号