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Surgical Treatments for Lentigo Maligna: A Review

机译：Lentigo Maligna的外科治疗：综述。

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BACKGROUND Since its initial description by Jonathan Hutchinson 120 years ago, a substantial amount of research has occurred to determine the optimum surgical therapy for lentigo maligna (LM).OBJECTIVE To summarize the literature regarding the surgical treatment of LM.METHODS We searched the National Library of Medicine using Pubmed Central and MEDLINE and included as many investigational reports regarding LM therapy that were available in an attempt to form a comprehensive review of surgical modalities. The key words "lentigo maligna," "lentigo maligna treatment," "lentigo maligna therapy," and "lentigo maligna therapeutic modalities" were used.RESULTS We included 12 studies examining staged surgical excision (SSE), nine using Mohs micro-graphic surgery (MMS), six investigating cryosurgery, 22 investigating imiquimod, seven using lasers, nine investigating radiation therapy, and two investigating electrosurgery and curettage.CONCLUSIONS SSE and MMS are associated with the lowest recurrence rates for LM. Cryotherapy and radiation therapy may be considered the options for treatment of LM in patients who cannot tolerate surgery. Imiquimod, although not currently approved by the FDA, has shown some efficacy in limited experimental studies and may play a future role in the treatment of LM.
机译：背景技术自从Jonathan Hutchinson于120年前对它的最初描述以来，已经进行了大量的研究来确定针对恶性紫癜（LM）的最佳手术治疗方法。目的总结有关LM手术治疗的文献。方法我们检索了国家图书馆使用Pubmed Central和MEDLINE进行医学研究，并纳入了许多与LM治疗有关的研究报告，以试图对手术方式进行全面回顾。结果使用了关键词“恶性青光眼”，“恶性青光眼治疗”，“恶性青光眼治疗”和“恶性青光眼治疗方式”。结果我们包括12项研究分阶段手术切除（SSE）的研究，其中9项使用了Mohs显微照相术（MMS），6个研究冷冻手术，22个研究咪喹莫特，7个使用激光，9个研究放射疗法以及2个研究电外科和刮除术。结论SSE和MMS与LM复发率最低相关。对于不能耐受手术的患者，可以将冷冻疗法和放射疗法视为LM的治疗选择。咪喹莫特虽然目前尚未获得FDA的批准，但在有限的实验研究中已显示出某些功效，并可能在LM的治疗中发挥未来作用。

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