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首页> 外文期刊>Developmental disabilities research reviews. >Structural and functional neuroimaging in Klinefelter (47,XXY) syndrome: a review of the literature and preliminary results from a functional magnetic resonance imaging study of language.
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Structural and functional neuroimaging in Klinefelter (47,XXY) syndrome: a review of the literature and preliminary results from a functional magnetic resonance imaging study of language.

机译:Klinefelter(47,XXY)综合征的结构和功能性神经影像学:文献综述和语言功能磁共振成像研究的初步结果。

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摘要

Klinefelter (47,XXY) syndrome (KS), the most common form of sex-chromosomal aneuploidy, is characterized by physical, endocrinologic, and reproductive abnormalities. Individuals with KS also exhibit a cognitive/behavioral phenotype characterized by language and language-based learning disabilities and executive and attentional dysfunction in the setting of normal general intelligence. The underlying neurobiologic mechanisms are just now beginning to be elucidated through structural and functional neuroimaging. Here, we review the literature of structural and functional neural findings in KS identified by neuroimaging and present preliminary results from a functional magnetic resonance imaging study examining brain activity during a verb generation task in KS.
机译:Klinefelter(47,XXY)综合征(KS)是性染色体非整倍性的最常见形式,其特征是身体,内分泌和生殖异常。患有KS的个体在正常的一般智力情况下还表现出以语言和基于语言的学习障碍以及执行和注意功能障碍为特征的认知/行为表型。刚刚通过结构和功能性神经影像学阐明了潜在的神经生物学机制。在这里,我们审查通过神经影像学鉴定的KS中的结构和功能性神经发现的文献,并提供功能磁共振成像研究的初步结果,该研究检查了KS中动词生成任务期间的大脑活动。

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