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首页> 外文期刊>Disease markers >Biological signatures of brain damage associated with high serum ferritin levels in patients with acute ischemic stroke and thrombolytic treatment
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Biological signatures of brain damage associated with high serum ferritin levels in patients with acute ischemic stroke and thrombolytic treatment

机译：急性缺血性脑卒中和溶栓治疗患者血清铁蛋白水平高与脑损伤的生物学特征

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Background and purpose: Increased body iron stores have been related to greater oxidative stress and brain injury in clinical and experimental cerebral ischemia and reperfusion. We aimed to investigate the biological signatures of excitotoxicity, inflammation and blood brain barrier disruption potentially associated with high serum ferritin levels-related damage in acute stroke patients treated with i.v. t-PA.Methods: Serum levels of ferritin (as index of increased cellular iron stores), glutamate, interleukin-6, matrix metalloproteinase-9 and cellular fibronectin were determined in 134 patients treated with i.v. t-PA within 3 hours from stroke onset in blood samples obtained before t-PA treatment, at 24 and 72 hours.Results: Serum ferritin levels before t-PA infusion correlated to glutamate (r = 0.59, p < 0.001) and interleukin-6 (r = 0.55, p < 0.001) levels at baseline, and with glutamate (r = 0.57, p < 0.001), interleukin-6 (r = 0.49, p < 0.001), metalloproteinase-9 (r = 0.23, p = 0.007) and cellular fibronectin (r = 0.27, p = 0.002) levels measured at 24 hours and glutamate (r = 0.415, p < 0.001), interleukin-6 (r = 0.359, p < 0.001) and metalloproteinase-9 (r = 0.261, p = 0.004) at 72 hours. The association between ferritin and glutamate levels remained after adjustment for confounding factors in generalized linear models. Conclusions: Brain damage associated with increased iron stores in acute ischemic stroke patients treated with iv. tPA may be mediated by mechanisms linked to excitotoxic damage. The role of inflammation, blood brain barrier disruption and oxidative stress in this condition needs further research.
机译：背景和目的：在临床和实验性脑缺血和再灌注中，体内铁储备的增加与更大的氧化应激和脑损伤有关。我们的目的是研究经静脉内注射治疗的急性中风患者，可能与高血清铁蛋白水平相关的损伤相关的兴奋性毒性，炎症和血脑屏障破坏的生物学特征。方法：在134例接受静脉注射治疗的患者中测定了血清铁蛋白（作为增加的细胞铁储备的指标），谷氨酸，白介素-6，基质金属蛋白酶9和细胞纤连蛋白的水平。在t-PA治疗前，24和72小时内获得的血样中风发作后3小时内的t-PA结果。t-PA输注前的血清铁蛋白水平与谷氨酸（r = 0.59，p <0.001）和白介素-基线时水平为6（r = 0.55，p <0.001），谷氨酸（r = 0.57，p <0.001），白介素6（r = 0.49，p <0.001），金属蛋白酶9（r = 0.23，p = 0.007）和细胞纤连蛋白（r = 0.27，p = 0.002）水平在24小时测量，谷氨酸（r = 0.415，p <0.001），白介素6（r = 0.359，p <0.001）和金属蛋白酶9（r = 0.2小时，p = 0.004）在72小时。校正线性模型中的混杂因素后，铁蛋白和谷氨酸水平之间的关联仍然存在。结论：静脉注射治疗的急性缺血性中风患者的脑损伤与铁储备增加有关。 tPA可能由与兴奋性毒性损害相关的机制介导。在这种情况下炎症，血脑屏障破坏和氧化应激的作用需要进一步研究。

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