QSAR of antineoplastics V: Exploration of receptor interaction sites of antitumor N-(7-indolyl)benzenesulfonamides targeting GI phase using electrotopological state atom index.

Roy K; Pal DK; Sengupta C

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QSAR of antineoplastics V: Exploration of receptor interaction sites of antitumor N-(7-indolyl)benzenesulfonamides targeting GI phase using electrotopological state atom index.

机译：VSAR的QSAR：使用电拓扑状态原子指数探索靶向GI期的抗肿瘤N-（7-吲哚基）苯磺酰胺的受体相互作用位点。

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Quantitative structure activity relationship (QSAR) study of antiproliferative activities of N-(7-indolyl)benzenesulfonamides with electrotopological state atom (ETSA) index corroborates the conclusions of the previously reported Hansch analysis that the structural requirements for interactions with receptors of human KB nasopharynx cell line are different from that for murine colon 38 and P388 leukemia cell lines. The study suggests that both phenyl ring and indole moiety are the important receptor interaction sites present on the ligands for the murine cell lines, while the latter site does not appear to play significant role in case of human KB cell carcinoma.

机译：具有电拓扑状态原子（ETSA）指数的N-（7-吲哚基）苯磺酰胺类抗增殖活性的定量结构活性关系（QSAR）研究证实了先前报道的Hansch分析的结论，即与人KB鼻咽细胞受体相互作用的结构要求该系与鼠结肠38和P388白血病细胞系不同。研究表明，苯环和吲哚部分都是鼠细胞系配体上重要的受体相互作用位点，而在人类KB细胞癌的情况下，后者似乎没有发挥重要作用。

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《Drug design and discovery》 |2001年第3期|共12页
作者
Roy K; Pal DK; Sengupta C;
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正文语种 eng
中图分类药学;
关键词
Antineoplastic Agents; G1 Phase; Receptors; Drug; Sulfonamides; 抗肿瘤药; G1期; 受体; 药物; 磺胺类;

机译：Antineoplastic Agents;G1 Phase;Receptors;Drug;Sulfonamides;抗肿瘤药;G1期;受体;药物;磺胺类;

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1. QSAR of antineoplastics V: Exploration of receptor interaction sites of antitumor N-(7-indolyl)benzenesulfonamides targeting GI phase using electrotopological state atom index. [J] . Roy K, Pal DK, Sengupta C Drug design and discovery . 2001,第3期

机译：VSAR的QSAR：使用电拓扑状态原子指数探索靶向GI期的抗肿瘤N-（7-吲哚基）苯磺酰胺的受体相互作用位点。
2. QSAR of antineoplastics IV: Hansch analysis of N-(7-indolyl)benzenesulfonamides against KB human nasopharynx carcinoma, colon 38 murine adenocarcinoma and P388 murine leukemia cell lines. [J] . Roy K, Pal DK, De AU, Drug design and discovery . 2001,第3期

机译：抗肿瘤药物的QSAR IV：针对KB人鼻咽癌，结肠38鼠腺癌和P388鼠白血病细胞系的N-（7-吲哚基）苯磺酰胺的Hansch分析。
3. QSAR of antineoplastics IV: Hansch analysis of N-(7-indolyl)benzenesulfonamides against KB human nasopharynx carcinoma, colon 38 murine adenocarcinoma and P388 murine leukemia cell lines. [J] . Roy K, Pal DK, De AU, Drug design and discovery . 2001,第3期

机译：抗肿瘤药物的QSAR IV：针对KB人鼻咽癌，结肠38鼠腺癌和P388鼠白血病细胞系的N-（7-吲哚基）苯磺酰胺的Hansch分析。
4. Exploration of device-circuit interactions in FinFET-based memories for sub-15nm technologies using a mixed mode quantum simulation framework: Atoms to systems [C] . Gupta Sumeet Kumar, Choday Sri Harsha, Roy Kaushik 2011 IEEE International Electron Devices Meeting . 2011

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机译：第一部分：杜卡霉素SA烷基化亚基的溶剂分解区域选择性和X射线结构。第二部分靶向促红细胞生成素受体的化合物库的溶液相合成。第三部分通过阻断蛋白酶MMP2和整联蛋白α（v）beta（3）的相互作用来识别新型血管生成抑制剂
6. Predicting Drug-Target Interactions with Electrotopological State Fingerprints and Amphiphilic Pseudo Amino Acid Composition [O] . Cheng Wang, Wenyan Wang, Kun Lu, 2020

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8. Prenatal Exposure to Methylmercury Alters Development of Adrenergic Receptor Binding Sites in Peripheral Sympathetic Target Tissues [R] . Slotkin, T. A. , Orband, L. , Cowdery, T. , 1987

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QSAR of antineoplastics V: Exploration of receptor interaction sites of antitumor N-(7-indolyl)benzenesulfonamides targeting GI phase using electrotopological state atom index.

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