Immune-competent human skin disease models

Bergers Lambert I. J. C.; Reijnders Christianne M. A.; van den Broek Lenie J.; Spiekstra Sander W.; de Gruijl Tanja D.; Weijers Ester M.; Gibbs Susan

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Immune-competent human skin disease models

机译：免疫能力强的人类皮肤疾病模型

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All skin diseases have an underlying immune component. Owing to differences in animal and human immunology, the majority of drugs fail in the preclinical or clinical testing phases. Therefore animal alternative methods that incorporate human immunology into in vitro skin disease models are required to move the field forward. This review summarizes the progress, using examples from fibrosis, autoimmune diseases, psoriasis, cancer and contact allergy. The emphasis is on co-cultures and 3D organotypic models. Our conclusion is that current models are inadequate and future developments with immune-competent skin-on-chip models based on induced pluripotent stem cells could provide a next generation of skin models for drug discovery and testing.

机译：所有皮肤疾病都有潜在的免疫成分。由于动物和人类免疫学的差异，大多数药物在临床前或临床测试阶段均失败。因此，需要将人类免疫学纳入体外皮肤疾病模型的动物替代方法来推动该领域的发展。本文以纤维化，自身免疫性疾病，牛皮癣，癌症和接触性过敏为例，总结了这一进展。重点是共培养和3D有机型模型。我们的结论是，当前的模型尚不完善，基于诱导多能干细胞的具有免疫功能的芯片上皮肤模型的未来开发可以为药物发现和测试提供下一代皮肤模型。

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《Drug discovery today》 |2016年第9期|共10页
作者
Bergers Lambert I. J. C.; Reijnders Christianne M. A.; van den Broek Lenie J.; Spiekstra Sander W.; de Gruijl Tanja D.; Weijers Ester M.; Gibbs Susan;
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正文语种 eng
中图分类药学;
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Immune-competent human skin disease models

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