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首页> 外文期刊>Drugs of today: Medicamentos de actualidad >TAVABOROLE TOPICAL SOLUTION, 5% FOR THE TREATMENT OF TOENAIL ONYCHOMYCOSIS
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TAVABOROLE TOPICAL SOLUTION, 5% FOR THE TREATMENT OF TOENAIL ONYCHOMYCOSIS

机译：TAVABOROLE局部用溶液，5％用于治疗趾甲甲癣

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摘要

Tavaborole topical solution, 5% (tavaborole) is a novel, boron-based, antifungal pharmaceutical agent indicated for treatment of toenail onychomycosis due to the dermatophytes Trichophyton rubrum or Trichophyton menta-grophytes. In preclinical studies, tavaborole effectively penetrated through full-thickness, non-diseased cadaver fingernails, including those with up to four layers of nail polish. Limited systemic absorption was observed following topical application of tavaborole. In phase III clinical trials involving patients with distal subungual onychomycosis affecting 20-60% of a target great toenail, significantly more patients treated with tavaborole versus vehicle achieved completely clear nail with negative mycology following daily application for 48 weeks. Treatment-emergent adverse events reported by at least 1% of patients treated with tavaborole and at a greater frequency versus vehicle included ingrown toenail, exfoliation, erythema and dermatitis. Treatment discontinuations were uncommon. Results from preclinical studies and phase III clinical trials establish tavaborole as a safe and efficacious treatment for toenail onychomycosis.
机译：Tavaborole局部用药溶液（5％）（Tavaborole）是一种新型的基于硼的抗真菌药物，可用于治疗由于皮肤癣菌或毛癣菌而引起的趾甲甲癣。在临床前研究中，他瓦伯罗有效地穿透了全厚度，未患病的尸体指甲，包括具有多达四层指甲油的指甲。在局部应用他巴硼罗后观察到有限的全身吸收。在III期临床试验中，涉及远端趾下甲癣影响到20-60％的目标大脚趾甲的患者，在每天使用48周后，与使用tavborole相比与媒介物治疗的患者明显多于完全阴性的真菌。至少有1％的接受tavborole治疗的患者报告了治疗时出现的不良事件，发生频率高于媒介物，包括趾甲长大，脱落，红斑和皮炎。中止治疗的情况很少见。临床前研究和III期临床试验的结果证实，tavborole是一种安全有效的趾甲甲癣治疗方法。

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