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CACHEXIA

机译：卡奇西亚

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Cachexia is a multiorgan, multifactorial and often irreversible wasting syndrome associated with cancer and other serious, chronic illnesses including AIDS, chronic heart failure, chronic kidney disease and chronic obstructive pulmonary disease. Treatment of the patient with cachexia is currently targeted to correcting the two underlying features of the condition: anorexia and metabolic disturbances. Greater understanding of the mechanisms behind cachexia and muscle wasting have led to new therapeutic possibilities, however. Several classes of drugs are under active development for cachexia including drugs acting on hormone receptors or cytokine receptors, myostatin/activin pathway antagonists, beta-adrenoceptor agonists and cannabinoids. This review will cover the pathophysiology, epidemiology, diagnosis, treatment, drug candidates under active development and targets for therapeutic intervention of cachexia.
机译：恶病质是与癌症和其他严重的慢性疾病（包括艾滋病，慢性心力衰竭，慢性肾脏病和慢性阻塞性肺病）相关的多器官，多因素且通常不可逆的消耗综合症。目前，恶病质患者的治疗目标是纠正该病的两个潜在特征：厌食和代谢紊乱。然而，对恶病质和肌肉消瘦背后的机制的更多了解导致了新的治疗可能性。恶病质的几种药物正在积极开发中，包括作用于激素受体或细胞因子受体的药物，肌生长抑制素/激活素途径拮抗剂，β-肾上腺素受体激动剂和大麻素。这篇综述将涵盖病理生理，流行病学，诊断，治疗，积极发展中的候选药物以及恶病质的治疗干预目标。

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