TENOFOVIR ALAFENAMIDE FUMARATE FOR THE TREATMENT OF HIV INFECTION

Sampath R.; Zeuli J.; Rizza S.; Temesgen Z.

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TENOFOVIR ALAFENAMIDE FUMARATE FOR THE TREATMENT OF HIV INFECTION

机译：富马酸替诺福尔阿芬酰胺治疗艾滋病毒感染

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Tenofovir alafenamide fumarate is a recently developed prodrug of tenofovir, a nucleotide analogue reverse transcriptase inhibitor with potent inhibitory activity against HIV. The utility of a previously developed tenofovir prodrug, tenofovir disoproxil fumarate, had been hampered by renal and bone mineral adverse events. Tenofovir alafenamide fumarate overcomes the shortcomings of tenofovir disoproxil fumarate by delivering high intracellular concentrations of the parent drug, tenofovir, while substantially reducing systemic exposure. Tenofovir alafenamide fumarate is currently available as a component of three fixed-dose products: i) coformulation with emtricitabine; ii) coformulation with elvitegravir, cobicistat and emtricitabine; and iii) coformulation with rilpivirine and emtricitabine.

机译：替诺福韦阿拉芬酰胺富马酸酯是替诺福韦的最新开发产品，替诺福韦是一种核苷酸类似物逆转录酶抑制剂，对HIV具有强抑制活性。先前开发的替诺福韦前药（富马酸替诺福韦二甲氧苄啶）的实用性受到肾脏和骨骼矿物质不良事件的阻碍。替诺福韦阿拉芬酰胺富马酸酯通过提供高浓度的母体药物替诺福韦细胞内浓度，同时大大降低了全身暴露，克服了替诺福韦双酚福马酸酯的缺点。替诺福韦阿拉芬酰胺富马酸酯目前可作为三种固定剂量产品的成分使用：i）与恩曲他滨共同配制; ii）与elvitegravir，cobicistat和恩曲他滨共同配制; iii）与利比韦林和恩曲他滨共同配制。

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《Drugs of today: Medicamentos de actualidad》 |2016年第11期|共9页
作者
Sampath R.; Zeuli J.; Rizza S.; Temesgen Z.;
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正文语种 eng
中图分类药学;
关键词
Tenofovir; Tenofovir alafenamide; HIV; AIDS; Antiretroviral therapy; Nucleotide reverse transcriptase inhibitors;

机译：替诺福韦;替诺福韦阿拉芬酰胺;艾滋病毒;艾滋病;抗逆转录病毒疗法;核苷酸逆转录酶抑制剂;

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1. Treatment with tenofovir alafenamide fumarate worsens the lipid profile of HIV‐infected patients versus treatment with tenofovir disoproxil fumarate, each coformulated with elvitegravir, cobicistat, and emtricitabine [J] . Cid‐Silva Purificación, Fernández‐Bargiela Noelia, Margusino‐Frami?án Luis, Basic & clinical pharmacology & toxicology. . 2019,第4期

机译：用替诺福韦富烯酰胺富马酸盐治疗艾滋病毒感染患者的脂质曲线与替诺福韦解毒富马酸薄荷酸，每次与ElviteGravir，Cobicistat和Emtrickabine的Coformulated
2. Efficacy and safety of the regimens containing tenofovir alafenamide versus tenofovir disoproxil fumarate in fixed-dose single-tablet regimens for initial treatment of HIV-1 infection: A meta-analysis of randomized controlled trials [J] . Xingbao Tao, Yanqiu Lu, Yihong Zhou, International journal of infectious diseases : . 2020,第3S1期

机译：含有Tenofovir Alafenamide的方案的疗效和安全性与固定剂单片中的替诺福韦毒素富马酸盐进行初始治疗HIV-1感染：随机对照试验的META分析
3. Efficacy and safety of emtricitabine/tenofovir alafenamide (FTC/TAF) vs. emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) as a backbone for treatment of HIV-1 infection in virologically suppressed adults: subgroup analysis by third agent of a randomized, double-blind, active-controlled phase 3 trial [J] . Post Frank A., Yazdanpanah Yazdan, Schembri Gabriel, HIV clinical trials . 2017,第3期

机译：Emtricicabine / Tenofovir Alafenaine（FTC / TAF）与Emtrickabine / Tenofovir Disoproxil umarate（FTC / TDF）作为用于治疗病毒学抑制成人的HIV-1感染的骨干的疗效和安全性：由随机的第三代理分析亚组分析 -blind，主动控制的第3阶段试验
4. Modeling and simulation for dynamics of tenofovir disoproxil fumarate anti-HBV infection therapy [C] . Xiao Chen, Jianlong Qiu, Weiqi Qin, Chinese Automation Congress . 2017

机译：替诺福韦富马酸替诺福韦抗乙肝病毒感染治疗动力学建模与仿真
5. PrEP Adherence to Tenofovir-Based Therapeutics Seems Efficacious in Reducing HIV Infection Dissemination: A Comparative Evaluation on the Therapeutic Potency of Tenofovir-Based PrEP & Dapivirine-Based Antiretroviral (ARV) Microbicide in HIV Prevention [D] . Paria, Ananya. 2019

机译：准备遵守基于Tenofovir的治疗方法似乎有效地减少HIV感染传播：对邻西罗韦的制备基础抗逆转录病毒（ARV）杀菌剂中幼虫预防杀菌剂的比较评价
6. Fanconi syndrome due to tenofovir disoproxil fumarate reversed byswitching to tenofovir alafenamide fumarate in an HIV-infectedpatient [O] . Nomvuyo Z. Mothobi, Jeffrey Masters, Deborah J. Marriott 2018

机译：替诺福韦富马酸替诺福韦酯逆转范可尼综合征在感染艾滋病毒的患者中改用替诺福韦阿拉芬酰胺富马酸酯患者
7. Treatment with tenofovir alafenamide fumarate worsens the lipid profile of HIV‐infected patients versus treatment with tenofovir disoproxil fumarate, each coformulated with elvitegravir, cobicistat, and emtricitabine [O] . Purificación Cid‐Silva, Noelia Fernández‐Bargiela, Luis Margusino‐Framiñán, 2018

机译：用替诺福韦富马酸盐治疗富马酸盐使艾滋病毒感染患者的脂质曲线与替诺福韦解毒富马酸盐进行治疗，每种与Elvitegravir，Cobicistat和Emtrickabine的Coformulated

TENOFOVIR ALAFENAMIDE FUMARATE FOR THE TREATMENT OF HIV INFECTION

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