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Cerebrovascular disease and dementia.

机译：脑血管疾病和痴呆。

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Cerebrovascular disease and dementia are extremely prevalent and disabling disorders affecting older people. Results of previous pathological investigations and later epidemiological studies have raised the possibility that the two disorders may be causally related. The study of such causal associations may provide insights that could lead to the development of strategies intended to prevent or treat dementia more effectively. Cerebrovascular disease has many manifestations, some of which are strong causal factors in the development of a future dementia. However, uncertainty and controversy exist regarding the presence and nature of the causal contribution of others. Potential therapeutic strategies for dementia are hindered by the lack of understanding of such relationships and the consequent difficulty in identifying a clear phenotype of dementia occurring predominantly due to cerebrovascular disease. The field is ripe for further examination of the associations between vascular factors and dementia,and the mechanisms underlying such associations. The interface between basic and clinical science has much to offer in clarifying the relationships between aging, vascular factors and cognitive decline in older people. In this review, we will attempt to synthesize data available from epidemiological, clinical and basic science research in the field of dementia related to cerebrovascular disease, highlighting potential avenues for further research.
机译：脑血管疾病和痴呆症是极为普遍的致残疾病，影响老年人。先前的病理学调查和后来的流行病学研究的结果提出了两种疾病可能因果相关的可能性。对这种因果关系的研究可能会提供一些见识，从而有助于制定旨在更有效地预防或治疗痴呆症的策略。脑血管疾病有许多表现，其中一些是未来痴呆症发展的强大因果因素。但是，关于他人因果贡献的存在和性质存在不确定性和争议。对痴呆症的潜在治疗策略因缺乏对这种关系的理解以及因此难以确定主要由脑血管疾病引起的痴呆症的清晰表型而受到阻碍。该领域为进一步研究血管因子与痴呆之间的关联以及这种关联的潜在基础奠定了基础。基础科学和临床科学之间的接口在阐明老年人的衰老，血管因子和认知能力下降之间的关系方面有很多作用。在这篇综述中，我们将尝试综合从与脑血管疾病有关的痴呆症的流行病学，临床和基础科学研究中获得的数据，从而突出进一步研究的潜在途径。

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