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首页> 外文期刊>DTW:Deutsche Tierarztliche Wochenschrift >Gingival fibromatosis (hereditary hyperplastic gingivitis) in a wild European red fox (Vulpes vulpes)
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Gingival fibromatosis (hereditary hyperplastic gingivitis) in a wild European red fox (Vulpes vulpes)

机译：欧洲野狐（Vulpes vulpes）中的牙龈纤维瘤病（遗传性增生性牙龈炎）

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摘要

This report. describes a case of gingival fibromatosis in an otherwise healthy and well nourished wild European red fox (Vulpes vulpes), which was shot by a hunter and submitted to the state laboratory in the context of the rabies monitoring program of the federal state of Brandenburg, Germany. At necropsy, a severe papillomatous proliferation of the complete gingival tissue of the upper and lower jaw was present. This gingival proliferation had already resulted in malocclusion, loosening and loss of several incisival, premolar and molar teeth. Histologically, the primary lesion was a massive increase in the amount of collagen rich and relatively avascular connective tissue within the gingival lamina propria mucosae. A papillomavirus infection was excluded by electron microscopy, immunohistochemistry and molecular biological methods. The gingival lesions in the red fox are identical to those seen in hereditary hyperplastic gingivitis in farmed silver foxes and hereditary gingival fibromatosis in man. It is presumed that, in analogy to the genetic diseases in silver foxes and man, a still unidentified genetic defect is responsible for the development of the disease in the red fox, too.
机译：此报告。描述了一例原发于健康且营养良好的野生欧洲红狐（Vulpes vulpes）的牙龈纤维瘤病，该病例由一名猎人拍摄，并在德国勃兰登堡州狂犬病监测计划的框架内提交州实验室。尸检时，出现上颌和下颌完整牙龈组织的严重乳头状增生。这种牙龈增生已经导致错牙合，松动和丢失了一些切牙，前磨牙和磨牙。从组织学上讲，原发灶是龈固有层粘膜内富含胶原蛋白和相对无血管的结缔组织大量增加。通过电子显微镜，免疫组织化学和分子生物学方法排除了乳头瘤病毒感染。赤狐的牙龈病变与人工养殖的​​银狐的遗传性增生性牙龈炎和人类的遗传性牙龈纤维瘤病相同。据推测，类似于银狐和人类中的遗传性疾病，仍未确定的遗传缺陷也导致了红狐中疾病的发展。

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