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首页> 外文期刊>Drugs and aging >Pneumococcal vaccination for older adults: the first 20 years.
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Pneumococcal vaccination for older adults: the first 20 years.

机译：老年人肺炎球菌疫苗接种：头20年。

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During the 20 years following its licensure, pneumococcal vaccine has not been widely used. Although the vaccine was shown to be efficacious in South African gold miners, clinical trials of 'pneumonia vaccine' in older adults that have attempted to demonstrate vaccine efficacy in preventing pneumonia have been inconclusive. Retrospective studies have convincingly demonstrated the effectiveness of vaccination in preventing invasive pneumococcal disease, but these findings have only gradually gained acceptance, largely because some observers reject the findings of observational studies or fail to appreciate the importance of invasive disease. In the 1980s, pneumococcal vaccine was used only in the US, but other countries began vaccination in the mid-1990s, in part due to a better understanding of the disease and the vaccine, but also because of concern about antimicrobial resistance. With greater understanding of the global importance of pneumococcal disease and the promise of conjugate and protein vaccines, during the next 20 years pneumococcal vaccines will become the most important vaccines for adults and children worldwide.
机译：在获得许可后的20年中，肺炎球菌疫苗尚未得到广泛使用。尽管该疫苗在南非的金矿中被证明是有效的，但在老年人中“肺炎疫苗”的临床试验试图证明疫苗预防肺炎的功效尚无定论。回顾性研究令人信服地证明了疫苗接种在预防侵袭性肺炎球菌疾病中的有效性，但这些发现仅逐渐被接受，主要是因为一些观察者拒绝观察性研究的发现或未能意识到侵袭性疾病的重要性。在1980年代，肺炎球菌疫苗仅在美国使用，但其他国家在1990年代中期开始进行疫苗接种，部分原因是对疾病和疫苗有了更好的了解，也由于对抗菌素耐药性的关注。随着对肺炎球菌疾病的全球重要性以及结合物和蛋白疫苗的前景的深入了解，在未来20年中，肺炎球菌疫苗将成为全世界成人和儿童最重要的疫苗。

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