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首页> 外文期刊>Drugs and aging >Value of endocrine therapy for early and locally advanced prostate cancer.
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Value of endocrine therapy for early and locally advanced prostate cancer.

机译：内分泌治疗对早期和局部晚期前列腺癌的价值。

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摘要

Prostate-specific antigen-based screening and increased public awareness of prostate cancer have led to earlier detection of localised and potentially curable tumour stages. Nevertheless, disease recurrence after radical treatment of prostate cancer remains a problem for a considerable number of patients. Endocrine therapy plays a role in the treatment of almost all stages of prostate cancer, either as definitive or as temporary therapy. Neoadjuvant hormonal treatment has its place mainly in the external beam radiotherapy setting, where it reduces target volume and adverse effects. When used prior to and during external beam radiotherapy, endocrine therapy has shown a survival advantage in the subset of patients with locally advanced prostate cancer (cT2-4, N0-1, M0) with Gleason scores 2-6. Several studies have shown that adjuvant endocrine treatment is able to delay disease progression in any stage. There is, however, an ongoing controversy regarding the possible survival benefit of such treatment that has to be balanced against its considerable adverse effects and costs. Survival improvements associated with adjuvant hormonal treatments have mainly been seen in patients with lymph node metastases or those with a high probability of micrometastatic disease. Several large studies are under way to investigate the role of adjuvant treatment in the field of early prostate cancer.
机译：前列腺特异的基于抗原的筛查和公众对前列腺癌认识的增强，导致更早地发现了局部且可能可治愈的肿瘤阶段。然而，对许多患者来说，根治性治疗前列腺癌后疾病复发仍然是一个问题。内分泌治疗在前列腺癌的几乎所有阶段中都可以发挥作用，无论是确定性治疗还是临时治疗。新辅助激素治疗主要在外照射治疗中发挥作用，可减少目标剂量和不良反应。当在外部束放射治疗之前和期间使用时，内分泌治疗在格里森评分为2-6的局部晚期前列腺癌（cT2-4，N0-1，M0）患者子集中显示出生存优势。几项研究表明，辅助内分泌治疗能够在任何阶段延迟疾病进展。然而，关于这种治疗的可能生存益处的争议一直存在，必须将其与相当大的副作用和成本进行权衡。与激素辅助治疗相关的生存改善主要见于淋巴结转移或微转移性疾病可能性高的患者。一些大型研究正在进行中，以研究辅助治疗在早期前列腺癌领域中的作用。

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