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首页> 外文期刊>Drug resistance updates: reviews and commentaries in antimicrobial and anticancer chemotherapy >Antifungal pharmacokinetics and pharmacodynamics: understanding the implications for antifungal drug resistance.
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Antifungal pharmacokinetics and pharmacodynamics: understanding the implications for antifungal drug resistance.

机译：抗真菌药代动力学和药效学：了解抗真菌药物耐药性的含义。

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摘要

Pharmacodynamics (PDs) describe the relationship between drug exposure and outcome. The drug exposures in these analyses are most commonly expressed in a variety of pharmacokinetic terms. The outcome of interest with anti-infective therapy is either microbiologic resolution or a clinical surrogate of treatment efficacy. An in vitro measure of drug potency, such as the minimum inhibitory concentration (MIC) is also frequently considered in this relationship. Examination of the relationships among drug pharmacokinetics, MIC, and efficacy has provided a framework for choice of antifungal drug and dose. These analyses provide a PD target for drug class/organism combinations. The PD target can be useful for defining the upper MIC limit for a drug-dosing regimen that would be expected to result in treatment efficacy. The PD target can be used to optimize dosing regimens and to aid in defining susceptibility breakpoints.
机译：药效学（PDs）描述了药物暴露与疗效之间的关系。这些分析中的药物暴露最通常以各种药代动力学术语表示。抗感染治疗的关注结果是微生物学分辨率或治疗功效的临床替代。在这种关系中也经常考虑药物效力的体外测量，例如最小抑制浓度（MIC）。对药物药代动力学，MIC和功效之间关系的检验为选择抗真菌药物和剂量提供了框架。这些分析为药物类别/生物组合提供了PD指标。 PD靶标可用于定义药物给药方案的MIC上限，该上限有望导致治疗效果。 PD目标可用于优化给药方案并帮助定义药敏性断点。

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