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首页> 外文期刊>Circulation journal >Quantitative Analysis of Myocardial Contrast Enhancementby First-Pass 64-Multidetector Computed Tomographyin Patients With Coronary Heart Disease
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Quantitative Analysis of Myocardial Contrast Enhancementby First-Pass 64-Multidetector Computed Tomographyin Patients With Coronary Heart Disease

机译：冠心病患者首过64层多层螺旋CT增强造影定量分析

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Background Although multidetector computed tomography (MDCT) allows non-invasive assessment of coronary artery stenosis, the presence of calcified lesions often lead to an overestimation of the stenosis. The present study was an evaluation of whether enhancement of first-pass myocardial data can improve the diagnostic accuracy of 64-MDCT.Methods and Results Data from 70 patients with single-vessel disease who underwent 64-MDCT followed by catheter-based coronary angiography (CAG) were analyzed. Myocardial enhancement was quantified by exaimining the signal densities at diastole. Among a total of 83 plaque segments, 35 calcified plaque segments were detected and 46 segments were found to have more than 50% coronary stenosis on catheter-based CAG. The average diameter stenosis was 75.2+-12.8%. Diagnosis by 64-MDCT of significant stenosis (segment-based analysis) had a sensitivity, specificity and accuracy for segments without calcified lesions of 92%, 100% and 99.7%, respectively, and 95.2%, 50%, and 77.1%, respectively, for calcified lesions. Taking into account the myocardial enhancement by calculating the decrease of the standardized signal densities in percent, these parameters could be improved to 95.2%, 85.7% and 91.4%, respectively, for segments with calcified lesions. Conclusions The diagnostic accuracy of 64-MDCT for stenosis with calcified lesions in particular can be improved by taking into account the myocardial enhancement data.
机译：背景技术尽管多层计算机断层扫描（MDCT）可以对冠状动脉狭窄进行非侵入性评估，但钙化病变的存在通常会导致对狭窄的高估。本研究评估了增强首过心肌数据是否可以提高64-MDCT的诊断准确性。方法和结果70例接受64-MDCT的单支血管疾病患者，然后进行基于导管的冠状动脉造影检查（ CAG）进行了分析。通过检查舒张期的信号密度来量化心肌增强。在总共83个斑块节段中，检测到35个钙化斑块节段，发现46个节段在基于导管的CAG上具有超过50％的冠状动脉狭窄。平均直径狭窄为75.2±-12.8％。通过64-MDCT诊断严重狭窄（基于段的分析）对于无钙化病变的段的敏感性，特异性和准确性分别为92％，100％和99.7％，以及95.2％，50％和77.1％ ，用于钙化病变。通过计算标准化信号密度的降低百分比来考虑心肌增强，对于钙化病变段，这些参数可以分别提高到95.2％，85.7％和91.4％。结论64-MDCT对心肌钙化病变狭窄的诊断准确性可通过考虑心肌增强数据而提高。

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