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首页> 外文期刊>Circulation journal >Inhibition of the Renin-Angiotensin System Prevents Re-Hospitalization of Heart Failure Patients With Preserved Ejection Fraction
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Inhibition of the Renin-Angiotensin System Prevents Re-Hospitalization of Heart Failure Patients With Preserved Ejection Fraction

机译：抑制肾素-血管紧张素系统可防止心力衰竭患者保留射血分数而再次住院

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Background Approximately half of the patients with chronic heart failure (CHF) show preserved systolic function, but less is known about CHF with preserved ejection fraction (EF).Methods and Results In a retrospective analysis, patients with CHF who had been admitted to hospital were divided into 2 groups: reduced EF (EF <= 40%) and preserved EF (EF >40%). The rate of preserved EF was 53.5% and those with preserved EF were older, more likely to be female, and had a lower serum hemoglobin concentration than those in the reduced EF group. In the multivariate analysis, only older age was independently related to CHF with preserved EF. CHF patients with preserved EF who were successfully discharged from hospital and then followed at the outpatient clinic were reviewed and re-hospitalization for CHF was examined by Cox hazard univariate analysis, which showed that prior CHF hospitalization, absence of hypertension, and non-use of angiotensin-convertingenzyme inhibitor (ACEI) and/or angiotensin-receptor blocker (ARB) were predictors. In the multivariate analysis, non-use of ACEI/ARB was the sole predictor for CHF re-hospitalization. Conclusions CHF patients with preserved EF are older than those with reduced EF and use of ACEI/ARB prevents their re-hospitalization.
机译：背景大约一半的慢性心力衰竭（CHF）患者表现出收缩功能保留，但对射血分数（EF）保留的CHF知之甚少。方法和结果回顾性分析显示，入院的CHF患者为分为2组：EF降低（EF <= 40％）和EF保留（EF> 40％）。 EF保留率是53.5％，EF保留者比衰老EF组的年龄更大，更有可能是女性，并且血清血红蛋白浓度较低。在多变量分析中，只有老年与EF保留的CHF独立相关。已成功出院然后在门诊就诊的EF保留下来的CHF患者进行了回顾，并通过Cox风险单因素分析对CHF的再次住院进行了检查，结果表明先前进行过CHF住院治疗，无高血压和不使用CHF血管紧张素转换酶抑制剂（ACEI）和/或血管紧张素受体阻滞剂（ARB）是预测因素。在多变量分析中，不使用ACEI / ARB是CHF再次住院的唯一预测因素。结论EF保留的CHF患者比EF降低的CHF患者年龄大，使用ACEI / ARB可以防止他们再次住院。

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