• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>JAMA otolaryngology-- head & neck surgery >Transoral robotic surgery for oropharyngeal cancer: Long-term quality of life and functional outcomes
【24h】

Transoral robotic surgery for oropharyngeal cancer: Long-term quality of life and functional outcomes

机译：经口机器人手术治疗口咽癌：长期生活质量和功能预后

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

IMPORTANCE: Because treatment for oropharyngeal squamous cell carcinoma (OPSCC), especially in patients of older age, is associated with decreased patient quality of life (QOL) after surgery, demonstration of a less QOL-impairing treatment technique would improve patient satisfaction substantially. OBJECTIVE: To determine swallowing, speech, and QOL outcomes following transoral robotic surgery (TORS) for OPSCC. DESIGN, PARTICIPANTS, AND SETTING: This prospective cohort study of 81 patients with previously untreated OPSCC was conducted at a tertiary care academic comprehensive cancer center. INTERVENTIONS: Primary surgical resection via TORS and neck dissection as indicated. MAIN OUTCOMES AND MEASURES: Patients were asked to complete the Head and Neck Cancer Inventory (HNCI) preoperatively and at 3 weeks as well as 3, 6, and 12 months postoperatively. Swallowing ability was assessed by independence from a gastrostomy tube (G-tube). Clinicopathologic and follow-up data were also collected. RESULTS: Mean follow-up time was 22.7 months. The HNCI response rates at 3 weeks and 3, 6, and 12 months were 79%, 60%, 63%, and 67% respectively. There were overall declines in speech, eating, aesthetic, social, and overall QOL domains in the early postoperative periods. However, at 1 year post TORS, scores for aesthetic, social, and overall QOL remained high. Radiation therapy was negatively correlated with multiple QOL domains (P < .05 for all comparisons), while age older than 55 years correlated with lower speech and aesthetic scores (P < .05 for both). Human papillomavirus status did not correlate with any QOL domain. G-tube rates at 6 and 12 months were 24% and 9%, respectively. Greater extent of TORS (>1 oropharyngeal site resected) and age older than 55 years predicted the need for a G-tube at any point after TORS (P < .05 for both). CONCLUSIONS AND RELEVANCE: Patients with OPSCC treated with TORS maintain a high QOL at 1 year after surgery. Adjuvant treatment and older age tend to decrease QOL. Patients meeting these criteria should be counseled appropriately.
机译：重要信息：由于口咽鳞状细胞癌（OPSCC）的治疗（尤其是老年患者）与术后术后患者的生活质量（QOL）降低有关，因此，减少QOL损害治疗技术的证明将大大改善患者的满意度。目的：确定OPSCC经口机器人手术（TORS）后的吞咽，言语和QOL结果。设计，参与者和背景：这项前瞻性队列研究在81例先前未接受过OPSCC治疗的患者中，是在三级医疗学术综合癌症中心进行的。干预措施：按照指示，通过TORS和颈部解剖进行一次手术切除。主要结果和测量指标：要求患者在术前，术后3周以及术后3、6、12个月完成头颈癌库存量（HNCI）。通过独立于胃造口管（G型管）评估吞咽能力。还收集了临床病理和随访数据。结果：平均随访时间为22.7个月。 HNCI在3周和3、6、12个月时的应答率分别为79％，60％，63％和67％。术后早期，言语，饮食，审美，社交和总体QOL领域总体下降。但是，在TORS发布后的第一年，美学，社交和总体QOL得分仍然很高。放射治疗与多个QOL域呈负相关（所有比较，P <.05），而年龄大于55岁的年龄与较低的言语和审美得分（两个均P <.05）相关。人乳头瘤病毒状态与任何QOL域均不相关。 6个月和12个月时的G管发生率分别为24％和9％。 TORS的范围更大（切除了> 1个口咽部位）且年龄大于55岁，这预示在TORS之后的任何时候都需要使用G管（两者均P <.05）。结论和相关性：接受TORS治疗的OPSCC患​​者术后1年维持较高的生活质量。辅助治疗和老年人倾向于降低生活质量。符合这些标准的患者应适当咨询。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号