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首页> 外文期刊>Journal of applied biological chemistry >Isoflavone Daidzein: Chemistry and Bacterial Metabolism
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Isoflavone Daidzein: Chemistry and Bacterial Metabolism

机译：异黄酮黄豆苷元：化学和细菌代谢

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摘要

Isoflavone daidzein is a phytoestrogen widely distributed in Leguminosae and is especially rich in the soybean. The C6-C3 (rings B and C) unit of isoflavones is derived from the phenylpropanoid pathway and the remaining C6 (ring A) unit is from the polyketide pathway. This unique carbon skeleton is the result of isomerization of the flavone catalyzed by the isoflavone synthase, a cytochrome P450 enzyme. The isoflavones daidzein and genistein are present in the plant mostly in the glucosylated forms.However, in the human intestine, the glycosidic linkage is broken, and the free form is uptaked into blood stream. The free form is further metabolized into various reduction products to end up at the equol, which is known to have the most potent estrogenic effect among the metabolites. Several human intestinal bacteria that can convert daidzein into equol have been described, and the study into the chemistry and biochemistry of the daizein reduction would be rewarding to the improvement of the human health.
机译：异黄酮黄豆苷元是一种植物雌激素，广泛分布在豆科中，尤其富含大豆。异黄酮的C6-C3（B和C环）单元是从苯丙烷途径衍生而来的，其余的C6（A环）单元是从聚酮化合物途径衍生的。这种独特的碳骨架是异黄酮合酶（一种细胞色素P450酶）催化的黄酮异构化的结果。植物中的异黄酮黄豆苷元和染料木黄酮主要以糖基化形式存在，但是在人的肠道中，糖苷键被破坏，自由形式被吸收到血液中。游离形式进一步代谢为各种还原产物，最终生成雌马酚，雌马酚在这些代谢物中具有最强的雌激素作用。已经描述了几种可以将黄豆苷元转化为雌马酚的人体肠道细菌，对黄豆苷元还原的化学和生物化学的研究将对改善人类健康有所帮助。

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