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首页> 外文期刊>Journal of applied toxicology >Percutaneous absorption of trinitrobenzene: animal models for human skin.
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Percutaneous absorption of trinitrobenzene: animal models for human skin.

机译：三硝基苯的经皮吸收：人类皮肤的动物模型。

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摘要

The percutaneous absorption of 1,3,5-trinitrobenzene (TNB) was studied in viable skin from hairless guinea pigs (HGP), Fischer 344 rats and humans. Skin was dermatomed and assembled in flow-through diffusion cells followed by TNB application in either an acetone or a water vehicle. Skin absorption was expressed as the percentage of applied dose absorbed into skin and receptor fluid within 24 h. Rapid absorption of TNB by rodent skin was obtained with both vehicles. For HGP skin, TNB absorption was 72.7+/-5.5% in the acetone vehicle and 82.3+/-4.5% in the water vehicle. For rat skin, TNB absorption was 61.0+/-4.1% (acetone) and 66.5+/-4.1% (water). Absorption of TNB from acetone was significantly reduced (38.0+/-11.0%, P = 0.0118) in human skin, but absorption from water remained high (75.5+/-10.8%). Little TNB remained in skin when a thin (200 microm) dermatome section was used (HGP and human skin). A thicker dermatome section was required (350 microm) with haired rat skin, and 13-21% of the absorbed radioactivity remained in the skin at 24 h. Rodent skin did not simulate satisfactorily the barrier properties of human skin when TNB absorption was reduced by application in a volatile solvent.
机译：研究了无毛豚鼠（HGP），Fischer 344大鼠和人类在有活力的皮肤中1,3,5-三硝基苯（TNB）的经皮吸收。将皮肤皮化并在流通式扩散池中组装，然后在丙酮或水介质中施用TNB。皮肤吸收表示为在24小时内吸收到皮肤和受体液体中的应用剂量的百分比。两种媒介都获得了啮齿动物皮肤对TNB的快速吸收。对于HGP皮肤，丙酮介质中TNB的吸收为72.7 +/- 5.5％，水介质中为82.3 +/- 4.5％。对于大鼠皮肤，TNB吸收为61.0 +/- 4.1％（丙酮）和66.5 +/- 4.1％（水）。人体皮肤中TNB从丙酮中的吸收显着降低（38.0 +/- 11.0％，P = 0.0118），但从水中的吸收仍然很高（75.5 +/- 10.8％）。当使用薄的（200微米）皮刀切片（HGP和人类皮肤）时，皮肤中几乎没有残留的TNB。须用毛发的大鼠皮肤切开较厚的皮肤刀切片（350微米），并在24小时内保留13-21％的吸收放射性。当通过在挥发性溶剂中施用而减少TNB吸收时，啮齿动物的皮肤不能令人满意地模拟人皮肤的阻隔性能。

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