...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of applied toxicology >Toxicology of n-pentane (CAS no. 109-66-0).
【24h】

Toxicology of n-pentane (CAS no. 109-66-0).

机译：正戊烷的毒理学（CAS编号109-66-0）。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

n-Pentane (CAS no. 109-6-0) is a hydrocarbon solvent with an estimated production volume of 50000 metric tons in Europe. The present work was carried out to strengthen the toxicological information available for regulatory decision-making, particularly product classification, occupational exposure limits and risk assessment. The work described in this report was sponsored either by the Pentane Special Interest Group under the auspices of the Hydrocarbon Solvent Producers Association of CEFIC (European Chemical Industry Council) or by Exxon Chemical Europe. The following results were obtained: n-pentane was not acutely toxic by oral or inhalation routes, it was not a skin or eye irritant and did not induce skin sensitization. It did not exhibit cumulative toxicity at levels up to 20000 mg m(-3), which is approximately one-half of the lower explosive limit and the highest level considered safe to test. It did not induce developmental toxicity and was not mutagenic. From this and other existing information, it is concluded that n-pentane does not require classification for potential toxic hazards (as defined by Annex VI of the EU Dangerous Substance Directive, 1993), although the physical properties indicate that it would be appropriate to warn for the potential for aspiration. Further, there is no reason to reduce the current occupational exposure recommendations. Finally, although there are some safety issues relating to the flammability of n-pentane, the absence of any demonstrable toxicity at high treatment levels indicates that the risk of adverse health effects is minimal for all segments of the population.
机译：正戊烷（CAS编号109-6-0）是一种烃溶剂，在欧洲的估计产量为50000公吨。开展当前工作是为了加强可用于监管决策的毒理学信息，特别是产品分类，职业接触限值和风险评估。本报告中描述的工作是由CEFIC烃溶剂生产商协会（欧洲化学工业理事会）赞助的Pentane特别兴趣小组或由Exxon Chemical Europe赞助的。得到以下结果：正戊烷经口服或吸入途径没有急性毒性，对皮肤或眼睛无刺激性，不会引起皮肤过敏。在最高20000 mg m（-3）的水平下，它没有表现出累积毒性，这大约是爆炸下限和认为可以测试的最高水平的一半。它不会引起发育毒性，并且不会诱变。从该信息和其他现有信息得出的结论是，尽管物理性质表明应适当警告，但正戊烷不需要对潜在的毒性危害进行分类（定义见《欧盟危险物质指令，1993年》附件VI）。潜在的愿望。此外，没有理由减少当前的职业暴露建议。最后，尽管存在一些与正戊烷的可燃性有关的安全问题，但在高治疗水平下没有任何可证明的毒性表明，该人群所有阶层的不良健康影响的风险最小。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号