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首页> 外文期刊>Journal of applied toxicology >Interaction of exercise training and chronic ethanol ingestion on testicular antioxidant system in rat.
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Interaction of exercise training and chronic ethanol ingestion on testicular antioxidant system in rat.

机译：运动训练与慢性摄入乙醇对大鼠睾丸抗氧化系统的相互作用。

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Recent evidence has indicated that exercise as well as ethanol exerts oxidative stress on vital organs/tissues of the body. However, the combination of both on the testicular antioxidant system is not known. This study investigates the interactive effects of exercise training and chronic ethanol ingestion on the testicular antioxidant system in rats. Male Fisher-344 rats were treated as follows: sedentary control (SC); exercise training (ET) for 6.5 weeks; ethanol (2 g kg(-1), p.o.) for 6.5 weeks; and ET plus ethanol for 6.5 weeks. Exercise training significantly decreased copper-zinc superoxide dismutase (CuZn-SOD) activity and enzyme protein concentration (73% and 67% of SC), whereas manganese SOD (Mn-SOD) and catalase (CAT) activity significantly increased (157% and 141% of SC) in the testes of rat. Exercise training significantly decreased the testicular malondialdehyde (MDA) concentration (70% of SC). Chronic ethanol ingestion significantly decreased testicular CuZn-SOD activity, enzyme protein concentration and CAT activity (65, 70 and 47% of SC) in rats. Ethanol significantly increased the testicular MDA level (129% of SC). The combination of exercise training and chronic ethanol ingestion significantly decreased testicular CuZn-SOD protein, MDA and the reduced glutathione oxidized glutathione ratio (GSH/GSSG) by 62, 70 and 79%, respectively. The data suggest that exercise training provides protection whereas chronic ethanol ingestion exerts oxidative damage to the testes of rat. Exercise training seems to reduce the extent of oxidative damage caused by ethanol on the testes of rats.
机译：最近的证据表明，运动以及乙醇会对人体的重要器官/组织产生氧化应激。然而，两者在睾丸抗氧化剂系统上的组合尚不清楚。这项研究调查运动训练和慢性摄入乙醇对大鼠睾丸抗氧化系统的相互作用。雄性Fisher-344大鼠的治疗方法如下：久坐对照（SC）;运动训练（ET）6.5周;乙醇（2 g kg（-1），p.o.）6.5周;和ET加乙醇6.5周。运动训练显着降低了铜锌超氧化物歧化酶（CuZn-SOD）活性和酶蛋白浓度（SC的73％和67％），而锰SOD（Mn-SOD）和过氧化氢酶（CAT）活性则显着增加（157％和141）在大鼠睾丸中的％SC）。运动训练显着降低了睾丸丙二醛（MDA）浓度（SC的70％）。长期摄入乙醇可显着降低大鼠睾丸C​​uZn-SOD活性，酶蛋白浓度和CAT活性（SC的65％，70％和47％）。乙醇显着提高睾丸MDA水平（SC的129％）。运动训练和长期摄入乙醇相结合，可使睾丸CuZn-SOD蛋白，MDA显着降低，谷胱甘肽氧化型谷胱甘肽比率（GSH / GSSG）分别降低62％，70％和79％。数据表明，运动训练可提供保护，而长期摄入乙醇会对大鼠的睾丸产生氧化损伤。运动训练似乎可以减少乙醇对大鼠睾丸造成的氧化损伤的程度。

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