Conservation of Amino Acids into Multiple Alignments Involved in Pairwise Interactions in Three-Dimensional Protein Structures

Mounir Errami; Christophe Geourjon; Gilbert Deleage

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Conservation of Amino Acids into Multiple Alignments Involved in Pairwise Interactions in Three-Dimensional Protein Structures

机译：氨基酸保守参与三维蛋白质结构中成对相互作用的多重排列。

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We present an original strategy, that involves a bioinformatic software structure, in order to perform an exhaustive and objective statistical analysis of three-dimensional structures of proteins. We establish the relationship between multiple sequences alignments and various structural features of proteins. We show that amino acids implied in disulfide bonds, salt bridges and hydrophobic interactions are particularly conserved. Effects of identity, global similarity within alignments, and accessibility of interactions have been studied. Furthermore, we point out that the more variable the sequences within a multiple alignment, the more informative the multiple alignment. The results support multiple alignments usefulness for predictions of structural features.

机译：我们提出了一种原始策略，其中涉及一种生物信息学软件结构，以便对蛋白质的三维结构进行详尽而客观的统计分析。我们建立了多个序列比对和蛋白质的各种结构特征之间的关系。我们表明隐含在二硫键，盐桥和疏水相互作用中的氨基酸特别保守。研究了身份，比对中的全局相似性以及交互的可访问性的影响。此外，我们指出多重比对中序列的可变性越高，多重比对的信息量就越大。结果支持多重比对对结构特征的预测有用。

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《Journal of Bioinformatics and Computational Biology》 |2003年第3期|共16页
作者
Mounir Errami; Christophe Geourjon; Gilbert Deleage;
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正文语种 eng
中图分类细胞生物学;
关键词
Conservation; three-dimensionnal interactions; multiple alignment; similarity; accessibility;

机译：保护;三维相互作用;多重比对;相似性;可及性;

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1. Conservation of Amino Acids into Multiple Alignments Involved in Pairwise Interactions in Three-Dimensional Protein Structures [J] . Mounir Errami, Christophe Geourjon, Gilbert Deleage Journal of Bioinformatics and Computational Biology . 2003,第3期

机译：氨基酸保守参与三维蛋白质结构中成对相互作用的多重排列。
2. Global multiple protein-protein interaction network alignment by combining pairwise network alignments [J] . Jakob Dohrmann, Juris Puchin, Rahul Singh BMC Bioinformatics . 2015,第SUPPLEMENTa13期

机译：通过组合成对网络比对来实现全局多个蛋白质-蛋白质相互作用网络比对
3. Conservation of amino acids in multiple alignments: aspartic acid has unexpected conservation [J] . Fiser Andraacute, s, J. Barton Geoffrey, FEBS Letters . 1996,第2a3期

机译：氨基酸在多个比对中的保守性：天冬氨酸具有出乎意料的保守性
4. Prediction of protein-protein interaction types with amino acid index distribution and pairwise kernel SVM [C] . Ding Peng, Zhang Shao-Wu, Chen Wei, 2011 IEEE International Conference on Signal Processing, Communications and Computing (ICSPCC) . 2011

机译：具有氨基酸指数分布和成对核支持向量机的蛋白质-蛋白质相互作用类型预测
5. Hydroxyl radical-induced hydrogen/deuterium exchange: Identification of amino acid residues involved in peptide-protein interactions. [D] . Goshe, Michael Bryan. 1999

机译：羟基自由基诱导的氢/氘交换：鉴定参与肽-蛋白质相互作用的氨基酸残基。
6. Global multiple protein-protein interaction network alignment by combining pairwise network alignments [O] . Jakob Dohrmann, Juris Puchin, Rahul Singh 2015

机译：通过组合成对网络比对来实现全局多个蛋白质-蛋白质相互作用网络比对
7. Global multiple protein-protein interaction network alignment by combining pairwise network alignments [O] . 2015

机译：通过组合成对网络比对来实现全局多个蛋白质-蛋白质相互作用网络比对
8. 3-D Structure-Based Amino Acid Sequence Alignment of Esterases, Lipases and Related Proteins. [R] . Gentry, M. K., Doctor, B. P., Cygler, M., 1993

机译：基于三维结构的酯酶，脂肪酶和相关蛋白的氨基酸序列比对。

Conservation of Amino Acids into Multiple Alignments Involved in Pairwise Interactions in Three-Dimensional Protein Structures

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