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Discovering protein-protein interactions

机译:发现蛋白质间的相互作用

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摘要

The ongoing genomics and proteomics efforts have helped identify many new genes and proteins in living organisms. However, simply knowing the existence of genes and proteins does not tell us much about the biological processes in which they participate. Many major biological processes are controlled by protein interaction networks. A comprehensive description of protein–protein interactions is therefore necessary to understand the genetic program of life. In this tutorial, we provide an overview of the various current high-throughput methods for discovering protein–protein interactions, covering both the conventional experimental methods and new computational approaches.
机译:正在进行的基因组学和蛋白质组学工作已帮助鉴定活生物体中的许多新基因和蛋白质。但是,仅仅知道基因和蛋白质的存在并不能告诉我们它们参与的生物学过程的很多信息。许多主要的生物学过程受蛋白质相互作用网络控制。因此,对蛋白质间相互作用的全面描述对于理解生命的遗传程序很有必要。在本教程中,我们概述了发现蛋白质间相互作用的各种当前高通量方法,涵盖了常规实验方法和新的计算方法。

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