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首页> 外文期刊>Journal of Biomechanics >MATERIAL AND COMPOSITIONAL PROPERTIES OF SELECTIVELY DEMINERALIZED CORTICAL BONE
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MATERIAL AND COMPOSITIONAL PROPERTIES OF SELECTIVELY DEMINERALIZED CORTICAL BONE

机译：选择性半硬质骨的材料和组成特性

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Timed immersion in buffered ethylenediamine-tetraacetic acid (EDTA) was used to selectively alter the mineral content at each level in the cortical bone structural hierarchy. The effects on the mechanical behavior were investigated using a combination of experimental techniques which provide collectively a wide range of resolution (5 mu m to 3 mm). Optical microscopy and histological analysis demonstrated a heterogeneous structure consisting of a mineralized tissue core surrounded by a layer of demineralized tissue (collagen) whose thickness varied depending on the immersion time. The mechanical behaviors of treated samples with (intact) and without (core) the surrounding demineralized layer were evaluated using three-point flexure. Overall, the intact specimens became significantly less brittle with increased immersion time in buffered-EDTA. For the core specimens, there was a systematic decrease in the elastic flexural properties (E, sigma(e), epsilon(e)). The site-specific properties of the specimens were determined using microhardness testing, scanning acoustic microscopy, and wavelength dispersive analysis. The mineralization and site-specific properties of the mineralized cores were not significantly affected by buffered-EDTA immersion; however, histomorphometric analysis showed a decrease in the mineralized volume fraction via widening of the pre-existing vascular channels. The experimental hierarchy was effective in discerning site-specific property changes and the localized heterogeneities resulting from the buffered-EDTA treatment. Based on the results of this study, buffered-EDTA treatment can be used to facilitate the determination of material and physical properties of intact and demineralized tissues within a single cortical bone sample. [References: 54]
机译：定时浸入缓冲的乙二胺四乙酸（EDTA）中以选择性地改变皮质骨结构层次中每个水平的矿物质含量。使用组合提供广泛分辨率（5微米至3毫米）的实验技术，研究了对机械性能的影响。光学显微镜和组织学分析显示，异质结构由矿化的组织核心组成，被矿化的组织（胶原蛋白）层包围，其厚度随浸入时间而变化。使用三点弯曲评估了带有（完整）和没有（核心）周围的软化层的处理后样品的机械性能。总体而言，完整样品在EDTA缓冲液中的浸泡时间增加，脆性明显降低。对于核心标本，弹性挠曲特性（E，sigma（e），ε（e））有系统的降低。使用显微硬度测试，扫描声学显微镜和波长色散分析确定样品的特定部位特性。 EDTA缓冲液浸泡对矿化岩心的矿化作用和特定部位的特性没有显着影响。然而，组织形态计量学分析表明，矿化的体积分数通过增加先前存在的血管通道而减少。实验层次结构有效地识别了特定位置的特性变化和缓冲的EDTA处理产生的局部异质性。根据这项研究的结果，EDTA缓冲处理可用于确定单个皮质骨样品中完整和脱矿质组织的材料和物理特性。 [参考：54]

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