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首页> 外文期刊>Journal of Biomechanics >Effects of degeneration on the compressive and tensile properties of human meniscus
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Effects of degeneration on the compressive and tensile properties of human meniscus

机译：变性对人半月板的压缩和拉伸性能的影响

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摘要

Healthy menisci function within the joint to prevent the underlying articular cartilage from excessive loads. Understanding how mechanical properties of menisci change with degeneration can drive future therapeutic studies to prevent this degeneration. Thus, the goal of this study was to characterize both compressive and tensile moduli of human menisci with varying degrees of gross damage due to osteoarthritis (OA). Twenty four paired menisci were collected from total knee joint replacement patients and the menisci were graded on a scale from 0-4 according to level of gross meniscal degeneration with 0= normal and 4= full tissue maceration. Each meniscus was then sectioned into anterior and posterior regions and subjected to indentation relaxation tests. Samples were sliced into 1 mm thick strips, made into dumbbells using a custom punch, and pulled to failure. Significant decreases in instantaneous compressive modulus were seen in the lateral posterior region between grades 0 and 1 (36% decrease) and in the medial anterior regions between grades 1 and 2 (67% decrease) and 1 and 3 (72% decrease). Changes in equilibrium modulus where seen in the lateral anterior region between grades 1 and 2 (35% decrease), lateral posterior region between grades 0-2 (41% decrease), and medial anterior regions between grades 1 and 2(59% decrease), 1 and 3 (67% decrease), 2 and 4(54% decrease), and 3 and 4 (42% decrease). No significant changes were observed in tensile modulus across all regions and degenerative grades. The results of this study demonstrate the compressive moduli are affected even in early stages of gross degeneration, and continue to decrease with increased deterioration. However, osteoarthritic menisci retain a tensile modulus similar to that of previously reported healthy menisci. This study highlights progressive changes in meniscal mechanical compressive integrity as level of gross tissue degradation increases, and thus, early interventions should focus on restoring or preserving compressive integrity. (C) 2015 Elsevier Ltd. All rights reserved.
机译：关节内健康的半月板功能可防止潜在的关节软骨承受过度负荷。了解半月板的机械特性如何随着变性而改变可以推动未来的治疗研究，以防止这种变性。因此，本研究的目的是表征人半月板的压缩模量和拉伸模量，并具有不同程度的由于骨关节炎（OA）引起的严重损伤。从总膝关节置换患者中收集二十四对半月板，根据半月板总体退化程度将半月板分级为0-4，其中0 =正常，4 =全组织浸软。然后将每个半月板切成前区和后区，并进行压痕松弛测试。将样品切成1毫米厚的条，使用定制冲头制成哑铃，然后拉至断裂。在0和1级之间的外侧后方区域（降低36％）和在1和2级之间的内侧后部区域（降低67％）以及1和3之间的内侧前部区域（瞬时降低72％）中观察到瞬时压缩模量的显着降低。在1级和2级之间的外侧前部区域（降低35％），0-2级之间的外侧后部区域（降低41％）以及在1级和2级之间的内侧前部区域（降低59％）中观察到的平衡模量变化，1和3（减少67％），2和4（减少54％）以及3和4（减少42％）。在所有区域和退化等级的拉伸模量中均未观察到明显变化。这项研究的结果表明，即使在严重退化的早期，压缩模量也会受到影响，并随着退化的加剧而继续降低。但是，骨关节炎半月板的拉伸模量与先前报道的健康半月板相似。这项研究强调了随着总组织降解水平的提高，半月板机械抗压完整性的逐渐变化，因此，早期干预应着重于恢复或保持抗压完整性。 （C）2015 Elsevier Ltd.保留所有权利。

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