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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Degradation of calcium phosphate ceramics.
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Degradation of calcium phosphate ceramics.

机译：磷酸钙陶瓷的降解。

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摘要

Degradation of three types of sintered calcium phosphate ceramic spheres was investigated in vitro at low pH conditions (LPC) and in an in vivo model, that is, injection into a mouse peritoneal cavity. Degradation was observed under both conditions. The rate of degradation depended on the type of ceramic, with beta-TCP degrading faster than HA and HA degrading faster than FA. Degradation was characterized by dissolution of the necks and the formation of cracks and irregularities in the grains. Intraperitoneal injection of the spheres into a mouse peritoneal cavity led to the formation of foreign body granulomas in which degradation could be observed. The in vivo degradation pattern was similar to that observed in vitro, but longer implantation times resulted in a further degradation. Small fragments rich in Ca and P were present in inclusion bodies. Calcium phosphate crystals sometimes also were observed in mitochondria, many of which were subject to lysis. We observed that ceramic type and implantation period also were related to the number of dead cells in the granulomas. Furthermore, extracellular deposits were seen between cells and ceramic spheres. Ca and P and also Fe were detected in these deposits. The presence of Fe is indicative of a lysosomal origin and thus of exocytotic activity. Copyright 1999 John Wiley & Sons, Inc.
机译：在低pH条件（LPC）和体内模型（即注射到小鼠腹腔中）的体外研究了三种类型的烧结磷酸钙陶瓷球的降解。在两种条件下均观察到降解。降解速率取决于陶瓷的类型，其中β-TCP的降解速度比HA快，而HA的降解速度比FA快。降解的特征在于颈的溶解以及晶粒中裂纹和不规则物的形成。将球体腹膜内注射到小鼠腹膜腔内导致异物肉芽肿的形成，其中可观察到降解。体内降解模式与体外观察到的相似，但是更长的植入时间导致了进一步的降解。包涵体中存在富含钙和磷的小碎片。有时在线粒体中也观察到磷酸钙晶体，其中许多都发生了裂解。我们观察到陶瓷类型和植入期也与肉芽肿中死细胞的数量有关。此外，在细胞和陶瓷球之间看到细胞外沉积物。在这些沉积物中检测到了Ca和P以及Fe。 Fe的存在指示溶酶体来源，并因此指示胞吐活性。版权所有1999 John Wiley＆Sons，Inc.

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