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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Targeting of EGF-displayed protein nanoparticles with anticancer drugs
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Targeting of EGF-displayed protein nanoparticles with anticancer drugs

机译：用抗癌药物靶向EGF展示的蛋白质纳米颗粒

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The development of protein-based carriers for drug delivery has been well studied. We previously constructed a protein-based nanoparticle consisting of genetically engineered elastin-like polypeptides (ELPs) with a fused polyaspartic acid tail (ELPD). The size of the self-assembled ELPD nanoparticles was regulated by charged repulsion of the poly-aspartic acid chains. In the present study, epidermal growth factor (EGF) was genetically fused to the C-terminus of ELPD to impart an active targeting ability to the ELPD nanoparticles. We examined the nanoparticle formation with EGF as well as its targeting ability. ELPD with fused EGF was found to form nanoparticles that displayed multivalent EGFs on their surface. EGF-displayed nanoparticles loaded with the anti-cancer drug paclitaxel were internalized into cells overexpressing the EGF receptor, and induced cell death. (C) 2014 Wiley Periodicals, Inc.
机译：已经对用于药物递送的基于蛋白质的载体的开发进行了充分的研究。我们先前构建了一个基于蛋白质的纳米颗粒，该颗粒由具有融合的聚天冬氨酸尾巴（ELPD）的基因工程弹性蛋白样多肽（ELP）组成。通过聚天冬氨酸链的带电斥力调节自组装ELPD纳米粒子的大小。在本研究中，将表皮生长因子（EGF）遗传融合到ELPD的C末端，以赋予ELPD纳米粒子以主动靶向能力。我们检查了具有EGF的纳米颗粒形成及其靶向能力。发现具有融合的EGF的ELPD形成了在其表面上显示多价EGF的纳米颗粒。载有抗癌药紫杉醇的EGF展示的纳米颗粒被内化到过表达EGF受体的细胞中，并诱导细胞死亡。 （C）2014威利期刊公司

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