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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Self-assembled, fluorescent polymeric micelles of a graft copolymer containing carbazole for thermo-controlled drug delivery in vitro.
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Self-assembled, fluorescent polymeric micelles of a graft copolymer containing carbazole for thermo-controlled drug delivery in vitro.

机译：自组装的，含有咔唑的接枝共聚物的荧光聚合物胶束，用于体外热控释药。

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摘要

A novel thermosensitive amphiphilic graft copolymer PNIPAAm-g-PCbzEA appending carbazole group was successfully designed and synthesized by the free radical copolymerization of N-isopropylacrylamide with hydrophobic precursor polymers of vinyl-functionalized poly(2-(N-carbazolyl)ethyl acrylate) (PCbzEA) in DMF. The PNIPAAm-g-PCbzEA copolymer was characterized by FTIR, (1)H NMR, GPC analysis, UV-vis spectroscopy and fluorescence spectroscopy. The TEM observation shows that the graft copolymer may self-assemble into polymeric micelles exhibiting a nanospheric morphology within a narrow size range of 30-60 nm in aqueous solution. From the (1)H NMR and FTIR analysis, the polymer micelles are composed of hydrophobic PCbzEA segments as the cores and the hydrophilic PNIPAAm segements as outer shells. The resulting micelles exhibited the temperature sensitivity with a lower critical solution temperature (LCST) of 31.5 degrees C and a critical micelle concentration (CMC) of 12.9 mg/L in water. In the study of drug release, an "on-off" drug release profile was found in response to stepwise temperature changes between 20 and 40 degrees C. The cytotoxicity assays for vero cells shows good biocompatibility of the graft copolymer in vitro.
机译：通过N-异丙基丙烯酰胺与乙烯基官能化聚（2-（N-咔唑基）乙基丙烯酸酯）（PCbzEA）的疏水前体聚合物的自由基共聚合，成功设计并合成了一种新的带有咔唑基团的热敏两亲接枝共聚物PNIPAAm-g-PCbzEA ）。通过FTIR，（1）1 H NMR，GPC分析，UV-可见光谱和荧光光谱表征PNIPAAm-g-PCbzEA共聚物。 TEM观察表明，接枝共聚物可以自组装成聚合物胶束，在水溶液中在30-60nm的狭窄尺寸范围内表现出纳米球形形态。从（1）H NMR和FTIR分析，聚合物胶束由疏水的PCbzEA链段为核，亲水的PNIPAAm链节为外壳。所得的胶束表现出温度敏感性，在水中的临界溶液温度（LCST）较低，为31.5摄氏度，临界胶束浓度（CMC）为12.9 mg / L。在药物释放的研究中，响应于20到40摄氏度之间的逐步温度变化，发现了“开-关”药物释放曲线。vero细胞的细胞毒性测定显示了接枝共聚物在体外具有良好的生物相容性。

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