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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Assessment of tissue repair in full thickness chondral defects in the rabbit using magnetic resonance imaging transverse relaxation measurements.
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Assessment of tissue repair in full thickness chondral defects in the rabbit using magnetic resonance imaging transverse relaxation measurements.

机译：使用磁共振成像横向弛豫测量评估兔全层软骨缺损的组织修复。

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摘要

The purpose of this study was to determine if the noninvasive and nondestructive technique of magnetic resonance imaging could be used to quantify the amount of repair tissue that fills surgically-induced chondral defects in the rabbit. Sixteen 4-mm diameter full-thickness chondral defects were created. A photopolymerizable hydrogel was used to seal the defects as a treatment modality. At 5 weeks, the animals were sacrificed and the distal femur was subjected to MRI analyses at high field (9.4 T). The transverse relaxation time (T(2)) in each defect was measured. Histology and histomorphometric analysis were used to quantify the amount of repair tissue that filled each defect. The relationship between T(2) and percent tissue fill was found to fit well to a negatively sloped, linear model. The linear (Pearson's product-moment) correlation coefficient was found to be r = -0.82 and the associated coefficient of determination was r(2) = 0.67. This correlation suggests that the MRI parameter T(2) can be used to track changes in the amount of repair tissue that fills cartilage defects. This would be especially useful in in vivo cartilage tissue engineering studies that attempt to determine optimal biomaterials for scaffold design.
机译：这项研究的目的是确定磁共振成像的非侵入性和非破坏性技术是否可用于量化填充手术引起的兔软骨缺损的修复组织的数量。创建了16个直径为4 mm的全厚度软骨缺损。使用可光聚合的水凝胶密封缺陷作为治疗手段。在第5周，处死动物，并在高场（9.4 T）下对股骨远端进行MRI分析。测量每个缺陷的横向弛豫时间（T（2））。组织学和组织形态计量学分析用于量化填充每个缺损的修复组织的数量。发现T（2）与组织填充百分比之间的关系非常适合负斜率线性模型。线性（皮尔逊积矩）相关系数为r = -0.82，相关的测定系数为r（2）= 0.67。这种相关性表明，MRI参数T（2）可用于跟踪填充软骨缺损的修复组织数量的变化。这在体内软骨组织工程研究中特别有用，该研究试图确定用于支架设计的最佳生物材料。

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