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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Hydrogel based tissue mimicking phantom for in-vitro ultrasound contrast agents studies.
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Hydrogel based tissue mimicking phantom for in-vitro ultrasound contrast agents studies.

机译：基于水凝胶的组织模拟体模，用于体外超声造影剂研究。

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摘要

Ultrasound medical imaging (UMI) is the most widely used image analysis technique, and often requires advanced in-vitro set up to perform morphological and functional investigations. These studies are based on contrast properties both related to tissue structure and injectable contrast agents (CA). In this work, we present a three-dimensional structure composed of two different hydrogels reassembly the microvascular network of a human tissue. This phantom was particularly suitable for the echocontrastographic measurements in human microvascular system. This phantom has been characterized to present the acoustic properties of an animal liver, that is, acoustic impedance (Z) and attenuation coefficient (AC), in UMI signal analysis in particular; the two different hydrogels have been selected to simulate the target organ and the acoustic properties of the vascular system. The two hydrogels were prepared starting from cellulose derivatives to simulating the target organ parenchyma and using a PEG-diacrylate to reproduce the vascular system. Moreover, harmonic analysis was performed on the hydrogel mimicking the liver parenchyma hydrogel to evaluate the ultrasound (US) distortion during echographic measurement. The phantom was employed in the characterization of an experimental US CA. Perfect agreement was found when comparing the hydrogel acoustical properties materials with the corresponding living reference tissues (i.e., vascular and parenchimal tissue).
机译：超声医学成像（UMI）是使用最广泛的图像分析技术，通常需要先进的体外设置来进行形态学和功能研究。这些研究基于与组织结构和可注射造影剂（CA）相关的造影剂特性。在这项工作中，我们提出了三维结构，该结构由两种不同的水凝胶组成，它们重新组装了人体组织的微血管网络。这种体模特别适用于人体微血管系统中的超声造影测量。该体模的特征在于特别是在UMI信号分析中表现出动物肝脏的声学特性，即声阻抗（Z）和衰减系数（AC）。选择了两种不同的水凝胶来模拟目标器官和血管系统的声学特性。从纤维素衍生物开始模拟目标器官实质，并使用PEG-二丙烯酸酯复制血管系统，制备了两种水凝胶。此外，在模拟肝实质水凝胶的水凝胶上进行谐波分析，以评估超声检查期间超声（US）的畸变。幻影用于表征美国实验性CA。将水凝胶的声学特性材料与相应的活体参照组织（即血管和实质组织）进行比较时，发现完全吻合。

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