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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Suitability of differently designed matrix-based implant surface coatings: an animal study on bone formation.
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Suitability of differently designed matrix-based implant surface coatings: an animal study on bone formation.

机译：不同设计的基于基质的植入物表面涂层的适用性：关于骨骼形成的动物研究。

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INTRODUCTION: The aim of the present study was to assay how bone formation around dental implants is influenced by differently composed collagen matrices and RGD peptide as implant surface coatings compared to a sandblasted titanium surface. MATERIAL AND METHODS: Five different implant surface coatings were designed: titanium (sandblasted), collagen type I, collagen type I&III, RGD-peptide, and mineralized collagen. Sixty experimental implants of a square-shaped design were inserted into the mandibles of 12 minipigs, 3 months following extraction of the premolar teeth. During the 6-month study period, sequential polyfluorochrome labeling was performed. After sacrifice, bone implant contact (BIC) was evaluated using histologic and histomorphometric methods. RESULTS: New bone formation was observed against all implant surfaces. Polyfluorochrome labeling showed that bone growth started from the host bone in the majority of samples. The highest BIC was measured for collagen I and collagen I/III coated implants; however, significant differences between the coatings could not be found. CONCLUSION: Osseointegration was achieved for all implant surfaces. Although a statistically significant increase in BIC could not be demonstrated for the experimental coatings after the 6 months study period, there was also no discernible detrimental effect of the coatings in comparison to the uncoated titanium surfaces.
机译：简介：本研究的目的是分析与喷砂钛表面相比，不同组成的胶原蛋白基质和作为植入物表面涂层的RGD肽如何影响牙科植入物周围的骨形成。材料和方法：设计了五种不同的植入物表面涂层：钛（喷砂处理），I型胶原，I＆III型胶原，RGD肽和矿化胶原。在拔除前磨牙后三个月，将60个方形设计的实验性植入物插入12只小型猪的下颌骨中。在6个月的研究期内，进行了顺序的多荧光染料标记。处死后，使用组织学和组织形态学方法评估骨植入物接触（BIC）。结果：在所有植入物表面均观察到新的骨形成。多荧光染料标记表明，大多数样品中的骨骼生长始于宿主骨骼。胶原蛋白I和胶原蛋白I / III涂层植入物的BIC最高。但是，没有发现涂层之间的显着差异。结论：所有植入物表面均实现骨整合。尽管在6个月的研究期后无法证明实验涂层的BIC具有统计学上的显着提高，但与未涂层的钛表面相比，涂层也没有明显的有害作用。

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