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首页> 外文期刊>Journal of cardiopulmonary rehabilitation >The influence of short-term endurance training on the insulin blood level, binding, and degradation of 125I-insulin by erythrocyte receptors in patients after myocardial infarction.
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The influence of short-term endurance training on the insulin blood level, binding, and degradation of 125I-insulin by erythrocyte receptors in patients after myocardial infarction.

机译：短期耐力训练对心肌梗死患者胰岛素血药水平，红细胞受体结合和125 I-胰岛素降解的影响。

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PURPOSE: This study was directed toward establishing whether and to what extent, short-term endurance training influences the insulin blood level, and the binding and degradation of 125I-insulin by erythrocyte receptors in patients undergoing rehabilitation after myocardial infarction. METHODS: The study was conducted in a group of 60 patients who had had myocardial infarction within the past 1.5 to 3 months and who did not have arterial hypertension and diabetes mellitus. All the patients took a symptom-limited cardiopulmonary exercise test. Before and after the test, venous blood was collected to determine lactic acid and insulin blood levels as well as the binding and degradation of 125I-insulin. The study group was randomized into two subgroups. One subgroup entered into a 3-week in-patient rehabilitation course. The control group was discharged from the hospital and was given no recommendations for physical exercise. The same investigation was repeated 3 weeks later. RESULTS: In the patients (50%) with hyperinsulinemia (insulin resistance index, > 10 microIU/mL), which was detected during the first investigation, insulin blood level decreased from 23.9 +/- 4.4 to 15.0 +/- 1.9 microIU/mL (P < 0.05) after rehabilitation, whereas insulin binding increased from 0.67 +/- 0.05 to 0.85 +/- 0.08 pg 125I/10(11) erythrocytes (P < 0.05). In the control group, which included normal subjects and those with hyperinsulinemia, the results obtained during the first and second investigations showed no statistically significant changes when compared. CONCLUSIONS: The results suggest that a 3-week endurance training period during rehabilitation after myocardial infarction reduces insulin resistance in patients with hyperinsulinemia.
机译：目的：本研究旨在确定短期耐力训练是否以及在何种程度上影响胰岛素血药水平，以及在心肌梗死后接受康复治疗的患者中红细胞受体对125 I-胰岛素的结合和降解。方法：本研究是在60例患者中进行的，这些患者在过去的1.5到3个月内患有心肌梗塞，并且没有高血压和糖尿病。所有患者均进行了症状受限的心肺运动试验。在测试之前和之后，收集静脉血以确定乳酸和胰岛素的血液水平以及125 I-胰岛素的结合和降解。研究组被随机分为两个亚组。一个小组参加了为期3周的住院康复课程。对照组出院，不建议进行体育锻炼。 3周后重复相同的研究。结果：在首次研究中发现的高胰岛素血症（胰岛素抵抗指数，> 10 microIU / mL）的患者（50％）中，胰岛素血水平从23.9 +/- 4.4降至15.0 +/- 1.9 microIU / mL （P <0.05）康复后，而胰岛素结合从0.67 +/- 0.05 pg增加到0.85 +/- 0.08 pg 125I / 10（11）红细胞（P <0.05）。在包括正常受试者和高胰岛素血症受试者的对照组中，第一次和第二次研究获得的结果与对照组相比无统计学意义的变化。结论：结果表明，心肌梗死后康复期间的3周耐力训练期可降低高胰岛素血症患者的胰岛素抵抗。

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